Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275307165> ?p ?o ?g. }
- W2275307165 endingPage "13765" @default.
- W2275307165 startingPage "13760" @default.
- W2275307165 abstract "Tumor necrosis factor (TNF) is one of the most potent physiological inducers of the nuclear transcription factor kappa B (NF-kappa B). A key event in the activation of NF-kappa B is the rapid release of the inhibitory subunit I kappa B-alpha. Various inhibitors of serine-like proteases are shown to block TNF-mediated NF-kappa B activation as well as the disappearance of I kappa B-alpha immunoreactivity in primary murine T lymphocytes and in various human leukemic cell lines. The protease inhibitors did not block TNF-induced activation of either phosphatidylcholine-specific phospholipase C or acidic sphingomyelinase (SMase), indicating that the putative protease operates rather downstream of TNF signal transduction processes. I kappa B-alpha degradation could be directly induced by addition of sphingomyelinase or synthetic ceramide to a cell-free system, indicating a stringent coupling of SMase to the NF-kappa B activation pathway. SMase-induced I kappa B-alpha degradation was suppressed by the protease inhibitor dichloroisocoumarin. Together, the data suggest that a TNF-responsive sphingomyelinase triggers the rapid degradation of I kappa B-alpha through a serine-like protease, which appears to be crucial to the control of NF-kappa B activation." @default.
- W2275307165 created "2016-06-24" @default.
- W2275307165 creator A5010497925 @default.
- W2275307165 creator A5046315263 @default.
- W2275307165 creator A5051557119 @default.
- W2275307165 creator A5070597784 @default.
- W2275307165 creator A5078256743 @default.
- W2275307165 creator A5086472692 @default.
- W2275307165 date "1994-05-01" @default.
- W2275307165 modified "2023-10-18" @default.
- W2275307165 title "Sphingomyelinase activates proteolytic I kappa B-alpha degradation in a cell-free system." @default.
- W2275307165 cites W1507759000 @default.
- W2275307165 cites W1519798625 @default.
- W2275307165 cites W1570011224 @default.
- W2275307165 cites W1581414531 @default.
- W2275307165 cites W1594159276 @default.
- W2275307165 cites W163073416 @default.
- W2275307165 cites W1904292186 @default.
- W2275307165 cites W1969419107 @default.
- W2275307165 cites W1975437758 @default.
- W2275307165 cites W1976384164 @default.
- W2275307165 cites W1978611748 @default.
- W2275307165 cites W1981988641 @default.
- W2275307165 cites W1992080559 @default.
- W2275307165 cites W1993720213 @default.
- W2275307165 cites W2005484362 @default.
- W2275307165 cites W2008608024 @default.
- W2275307165 cites W2033684442 @default.
- W2275307165 cites W2035280748 @default.
- W2275307165 cites W2041576624 @default.
- W2275307165 cites W2041770258 @default.
- W2275307165 cites W2043666488 @default.
- W2275307165 cites W2047688511 @default.
- W2275307165 cites W2049781724 @default.
- W2275307165 cites W2051831012 @default.
- W2275307165 cites W2057093252 @default.
- W2275307165 cites W2061574494 @default.
- W2275307165 cites W2061903251 @default.
- W2275307165 cites W2070849933 @default.
- W2275307165 cites W2080475643 @default.
- W2275307165 cites W2087902603 @default.
- W2275307165 cites W2090745999 @default.
- W2275307165 cites W2093432306 @default.
- W2275307165 cites W2094003696 @default.
- W2275307165 cites W2127145932 @default.
- W2275307165 cites W2150571795 @default.
- W2275307165 cites W2171725615 @default.
- W2275307165 cites W2175093343 @default.
- W2275307165 doi "https://doi.org/10.1016/s0021-9258(17)36712-1" @default.
- W2275307165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8188652" @default.
- W2275307165 hasPublicationYear "1994" @default.
- W2275307165 type Work @default.
- W2275307165 sameAs 2275307165 @default.
- W2275307165 citedByCount "97" @default.
- W2275307165 countsByYear W22753071652012 @default.
- W2275307165 countsByYear W22753071652014 @default.
- W2275307165 countsByYear W22753071652015 @default.
- W2275307165 crossrefType "journal-article" @default.
- W2275307165 hasAuthorship W2275307165A5010497925 @default.
- W2275307165 hasAuthorship W2275307165A5046315263 @default.
- W2275307165 hasAuthorship W2275307165A5051557119 @default.
- W2275307165 hasAuthorship W2275307165A5070597784 @default.
- W2275307165 hasAuthorship W2275307165A5078256743 @default.
- W2275307165 hasAuthorship W2275307165A5086472692 @default.
- W2275307165 hasBestOaLocation W22753071651 @default.
- W2275307165 hasConcept C138885662 @default.
- W2275307165 hasConcept C159110408 @default.
- W2275307165 hasConcept C185592680 @default.
- W2275307165 hasConcept C2775944032 @default.
- W2275307165 hasConcept C2778724333 @default.
- W2275307165 hasConcept C2779679103 @default.
- W2275307165 hasConcept C41008148 @default.
- W2275307165 hasConcept C41895202 @default.
- W2275307165 hasConcept C49453240 @default.
- W2275307165 hasConcept C55493867 @default.
- W2275307165 hasConcept C64943373 @default.
- W2275307165 hasConcept C71924100 @default.
- W2275307165 hasConcept C76155785 @default.
- W2275307165 hasConcept C86803240 @default.
- W2275307165 hasConcept C95444343 @default.
- W2275307165 hasConceptScore W2275307165C138885662 @default.
- W2275307165 hasConceptScore W2275307165C159110408 @default.
- W2275307165 hasConceptScore W2275307165C185592680 @default.
- W2275307165 hasConceptScore W2275307165C2775944032 @default.
- W2275307165 hasConceptScore W2275307165C2778724333 @default.
- W2275307165 hasConceptScore W2275307165C2779679103 @default.
- W2275307165 hasConceptScore W2275307165C41008148 @default.
- W2275307165 hasConceptScore W2275307165C41895202 @default.
- W2275307165 hasConceptScore W2275307165C49453240 @default.
- W2275307165 hasConceptScore W2275307165C55493867 @default.
- W2275307165 hasConceptScore W2275307165C64943373 @default.
- W2275307165 hasConceptScore W2275307165C71924100 @default.
- W2275307165 hasConceptScore W2275307165C76155785 @default.
- W2275307165 hasConceptScore W2275307165C86803240 @default.
- W2275307165 hasConceptScore W2275307165C95444343 @default.
- W2275307165 hasIssue "19" @default.
- W2275307165 hasLocation W22753071651 @default.
- W2275307165 hasOpenAccess W2275307165 @default.