FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275325314> ?p ?o ?g. }

• W2275325314 endingPage "801" @default.
• W2275325314 startingPage "791" @default.
• W2275325314 abstract "ABSTRACT Lysosomal impairment is increasingly recognized as a central event in the pathophysiology of PD. Genetic associations between lysosomal storage disorders, including Gaucher disease and PD, highlight common risk factors and pathological mechanisms. Because the autophagy–lysosomal system is involved in the intralysosomal hydrolysis of dysfunctional proteins, lysosomal impairment may contribute to α‐synuclein aggregation in PD. The degradation of α‐synuclein is a complex process involving different proteolytic mechanisms depending on protein burden, folding, posttranslational modifications, and yet unknown factors. In this review, evidence for lysosomal dysfunction in PD and its intimate relationship with α‐synuclein aggregation are discussed, after which the question of whether lysosomal proteins may serve as diagnostic biomarkers for PD is addressed. Changes in lysosomal enzymes, such as reduced glucocerebrosidase and cathepsin levels, have been observed in affected brain regions in PD patients. The detection of lysosomal proteins in CSF may provide a read‐out of lysosomal dysfunction in PD and holds promise for the development of diagnostic PD biomarkers. Initial PD biomarker studies demonstrated altered lysosomal enzyme activities in CSF of PD patients when compared with controls. However, CSF lysosomal enzyme activities alone could not discriminate between PD patients and controls. The combination of CSF lysosomal markers with α‐synuclein species and indicators of mitochondrial dysfunction, inflammation, and other pathological proteins in PD may be able to facilitate a more accurate diagnosis of PD. Further CSF biomarker studies are needed to investigate the utility of CSF lysosomal proteins as measures of disease state and disease progression in PD. © 2016 International Parkinson and Movement Disorder Society" @default.
• W2275325314 created "2016-06-24" @default.
• W2275325314 creator A5019846852 @default.
• W2275325314 creator A5037832617 @default.
• W2275325314 creator A5061967495 @default.
• W2275325314 creator A5066276220 @default.
• W2275325314 creator A5071946210 @default.
• W2275325314 creator A5088823694 @default.
• W2275325314 creator A5091758293 @default.
• W2275325314 date "2016-02-29" @default.
• W2275325314 modified "2023-09-30" @default.
• W2275325314 title "Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links" @default.
• W2275325314 cites W1138449060 @default.
• W2275325314 cites W1205458192 @default.
• W2275325314 cites W1491957044 @default.
• W2275325314 cites W1499005366 @default.
• W2275325314 cites W1501190799 @default.
• W2275325314 cites W1502613487 @default.
• W2275325314 cites W1521681896 @default.
• W2275325314 cites W1527671059 @default.
• W2275325314 cites W1558149078 @default.
• W2275325314 cites W1558432922 @default.
• W2275325314 cites W1561899360 @default.
• W2275325314 cites W1572888768 @default.
• W2275325314 cites W1762620449 @default.
• W2275325314 cites W1771394546 @default.
• W2275325314 cites W1800113785 @default.
• W2275325314 cites W1825944839 @default.
• W2275325314 cites W1833122216 @default.
• W2275325314 cites W1852264095 @default.
• W2275325314 cites W1859468577 @default.
• W2275325314 cites W1866238768 @default.
• W2275325314 cites W1892074666 @default.
• W2275325314 cites W1907174433 @default.
• W2275325314 cites W1964057486 @default.
• W2275325314 cites W1964353444 @default.
• W2275325314 cites W1967105375 @default.
• W2275325314 cites W1971210732 @default.
• W2275325314 cites W1971217038 @default.
• W2275325314 cites W1973738022 @default.
• W2275325314 cites W1974250737 @default.
• W2275325314 cites W1976750661 @default.
• W2275325314 cites W1977442011 @default.
• W2275325314 cites W1982182604 @default.
• W2275325314 cites W1982224533 @default.
• W2275325314 cites W1983009765 @default.
• W2275325314 cites W1988619763 @default.
• W2275325314 cites W1989812344 @default.
• W2275325314 cites W1993467627 @default.
• W2275325314 cites W1995863785 @default.
• W2275325314 cites W1996637092 @default.
• W2275325314 cites W1998068808 @default.
• W2275325314 cites W1998385521 @default.
• W2275325314 cites W2000678720 @default.
• W2275325314 cites W2004213856 @default.
• W2275325314 cites W2006220351 @default.
• W2275325314 cites W2010810678 @default.
• W2275325314 cites W2011041694 @default.
• W2275325314 cites W2011048732 @default.
• W2275325314 cites W2012085559 @default.
• W2275325314 cites W2013067946 @default.
• W2275325314 cites W2017642230 @default.
• W2275325314 cites W2021590931 @default.
• W2275325314 cites W2021919397 @default.
• W2275325314 cites W2022649483 @default.
• W2275325314 cites W2026082530 @default.
• W2275325314 cites W2026175550 @default.
• W2275325314 cites W2027096397 @default.
• W2275325314 cites W2028072328 @default.
• W2275325314 cites W2029028848 @default.
• W2275325314 cites W2031365272 @default.
• W2275325314 cites W2039484126 @default.
• W2275325314 cites W2039736612 @default.
• W2275325314 cites W2039921716 @default.
• W2275325314 cites W2043291430 @default.
• W2275325314 cites W2052004580 @default.
• W2275325314 cites W2052594340 @default.
• W2275325314 cites W2052612294 @default.
• W2275325314 cites W2055310246 @default.
• W2275325314 cites W2056094172 @default.
• W2275325314 cites W2060573418 @default.
• W2275325314 cites W2063754694 @default.
• W2275325314 cites W2066304458 @default.
• W2275325314 cites W2068288454 @default.
• W2275325314 cites W2068292276 @default.
• W2275325314 cites W2069274491 @default.
• W2275325314 cites W2070363734 @default.
• W2275325314 cites W2071494035 @default.
• W2275325314 cites W2072066672 @default.
• W2275325314 cites W2073045617 @default.
• W2275325314 cites W2073449985 @default.
• W2275325314 cites W2076743021 @default.
• W2275325314 cites W2077047479 @default.
• W2275325314 cites W2079133058 @default.
• W2275325314 cites W2081455544 @default.
• W2275325314 cites W2085963598 @default.
• W2275325314 cites W2086189475 @default.
• W2275325314 cites W2090666699 @default.

• next