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- W2275339719 abstract "The initial step in olfactory sensation involves the binding of odorant molecules to specific receptor proteins on the ciliary surface of olfactory receptor cells (ORCs). Odorant receptors coupled to G-proteins activate adenylyl cyclase, leading to the generation of cAMP, which directly gates a cyclic nucleotide-gated (CNG) cationic channel in the ciliary membrane [1–5]. In contrast, odorants such as amyl acetate, limonene, and acetophenone (banana-, lemon-, and orange-blossom-like-odor) are also known to suppress the CNG current in ORCs [6]. Similar suppression was observed in various voltage-gated currents of olfactory cells [7–9]. It is thought that suppression influences the perception of odorant by masking odorant responses and by sharpening the odorant specificities in single cells. But it is unclear whether odorants suppress ion channels in ORCs specifically or whether they also suppress channels in other neurons generally. In the present study, we examined the effect of odorants on ionic channels in retinal cells, because they were well-characterized and could be treated easily. Although odorants are not stimulants or endogenous molecules in the retina, it would be interesting to elucidate biophysical and pharmacological properties of odorants against the ionic channels.Key wordsOdorantVoltage-gated channelCyclic nucleotide-gated channelGlutamate-gated channel" @default.
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- W2275339719 date "2003-01-01" @default.
- W2275339719 modified "2023-09-27" @default.
- W2275339719 title "Suppression by Odorants of Voltage-Gated and Ligand-Gated Channels in Retinal Neurons" @default.
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- W2275339719 doi "https://doi.org/10.1007/978-4-431-68447-3_53" @default.
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