Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275357480> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2275357480 abstract "Acute inhibition of nitric oxide (NO) synthase (NOS) augments the release of endothelium-derived contracting factor (EDCF). The present study investigates whether or not chronic inhibition of NOS modulates endothelium-dependent contractions (EDC). Eighteen weeks old male Sprague Dawley rats were treated for 6 weeks with vehicle or the NOS inhibitor, N-nitro-L-arginine methyl ester (L-NAME). Aortic rings with or without endothelium were used for isometric tension recording. Chronic NOS inhibition increased systolic blood pressure and reduced acetylcholine-induced relaxations in rings with endothelium. This reduction was reversed by L-arginine (1 mM). In quiescent aortic rings, A23187 caused contractions, which were greater in the presence of the endothelium and after L-NAME treatment. These contractions were abolished by the cyclooxygenase (COX)-2 (NS-398) but not the COX-1 (SC-560) inhibitor, and by the selective thromboxane (TP)-receptor antagonist (terutroban). In the treated group, COX-1 and COX-2 expressions, as determined by Western blotting, were up-regulated while the TP receptor expression remained unchanged, and eNOS expression and NO level became lower. These experiments demonstrate that chronic NOS inhibition in the rat enhances EDC by inducing COX-2 expression and augmenting the production of EDCF. (Supported by the Research Grant Council of Hong Kong)" @default.
- W2275357480 created "2016-06-24" @default.
- W2275357480 creator A5000707943 @default.
- W2275357480 creator A5027121686 @default.
- W2275357480 creator A5035777213 @default.
- W2275357480 creator A5049381048 @default.
- W2275357480 date "2008-03-01" @default.
- W2275357480 modified "2023-10-01" @default.
- W2275357480 title "Modulation of endothelium‐dependent contractions by chronic inhibition of nitric oxide synthase in the rat aorta" @default.
- W2275357480 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1128.7" @default.
- W2275357480 hasPublicationYear "2008" @default.
- W2275357480 type Work @default.
- W2275357480 sameAs 2275357480 @default.
- W2275357480 citedByCount "0" @default.
- W2275357480 crossrefType "journal-article" @default.
- W2275357480 hasAuthorship W2275357480A5000707943 @default.
- W2275357480 hasAuthorship W2275357480A5027121686 @default.
- W2275357480 hasAuthorship W2275357480A5035777213 @default.
- W2275357480 hasAuthorship W2275357480A5049381048 @default.
- W2275357480 hasConcept C121332964 @default.
- W2275357480 hasConcept C123079801 @default.
- W2275357480 hasConcept C126322002 @default.
- W2275357480 hasConcept C134018914 @default.
- W2275357480 hasConcept C164705383 @default.
- W2275357480 hasConcept C185592680 @default.
- W2275357480 hasConcept C24890656 @default.
- W2275357480 hasConcept C2776992346 @default.
- W2275357480 hasConcept C2777622882 @default.
- W2275357480 hasConcept C2778326061 @default.
- W2275357480 hasConcept C2779980429 @default.
- W2275357480 hasConcept C2992676626 @default.
- W2275357480 hasConcept C519581460 @default.
- W2275357480 hasConcept C71924100 @default.
- W2275357480 hasConcept C98274493 @default.
- W2275357480 hasConceptScore W2275357480C121332964 @default.
- W2275357480 hasConceptScore W2275357480C123079801 @default.
- W2275357480 hasConceptScore W2275357480C126322002 @default.
- W2275357480 hasConceptScore W2275357480C134018914 @default.
- W2275357480 hasConceptScore W2275357480C164705383 @default.
- W2275357480 hasConceptScore W2275357480C185592680 @default.
- W2275357480 hasConceptScore W2275357480C24890656 @default.
- W2275357480 hasConceptScore W2275357480C2776992346 @default.
- W2275357480 hasConceptScore W2275357480C2777622882 @default.
- W2275357480 hasConceptScore W2275357480C2778326061 @default.
- W2275357480 hasConceptScore W2275357480C2779980429 @default.
- W2275357480 hasConceptScore W2275357480C2992676626 @default.
- W2275357480 hasConceptScore W2275357480C519581460 @default.
- W2275357480 hasConceptScore W2275357480C71924100 @default.
- W2275357480 hasConceptScore W2275357480C98274493 @default.
- W2275357480 hasIssue "S1" @default.
- W2275357480 hasLocation W22753574801 @default.
- W2275357480 hasOpenAccess W2275357480 @default.
- W2275357480 hasPrimaryLocation W22753574801 @default.
- W2275357480 hasRelatedWork W1972240188 @default.
- W2275357480 hasRelatedWork W1973235700 @default.
- W2275357480 hasRelatedWork W1984322697 @default.
- W2275357480 hasRelatedWork W2014183143 @default.
- W2275357480 hasRelatedWork W2030474005 @default.
- W2275357480 hasRelatedWork W2032317876 @default.
- W2275357480 hasRelatedWork W2053152946 @default.
- W2275357480 hasRelatedWork W2173797565 @default.
- W2275357480 hasRelatedWork W2249960180 @default.
- W2275357480 hasRelatedWork W2261766924 @default.
- W2275357480 hasRelatedWork W2290701754 @default.
- W2275357480 hasRelatedWork W2355860209 @default.
- W2275357480 hasRelatedWork W2413063222 @default.
- W2275357480 hasRelatedWork W2788304933 @default.
- W2275357480 hasRelatedWork W2954383523 @default.
- W2275357480 hasRelatedWork W3100274119 @default.
- W2275357480 hasRelatedWork W3103795138 @default.
- W2275357480 hasRelatedWork W3146335277 @default.
- W2275357480 hasRelatedWork W3176076592 @default.
- W2275357480 hasRelatedWork W2412211087 @default.
- W2275357480 hasVolume "22" @default.
- W2275357480 isParatext "false" @default.
- W2275357480 isRetracted "false" @default.
- W2275357480 magId "2275357480" @default.
- W2275357480 workType "article" @default.