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• W2275405720 abstract "The metalloprotease meprin β cleaves the Alzheimer's Disease (AD) relevant amyloid precursor protein (APP) as a β-secretase reminiscent of BACE-1, however, predominantly generating N-terminally truncated Aβ2-x variants.Herein, we observed increased endogenous sAPPα levels in the brains of meprin β knock-out (ko) mice compared to wild-type controls. We further analyzed the cellular interaction of APP and meprin β and found that cleavage of APP by meprin β occurs prior to endocytosis. The N-terminally truncated Aβ2-40 variant shows increased aggregation propensity compared to Aβ1-40 and acts even as a seed for Aβ1-40 aggregation. Additionally, we observed that different APP mutants affect the catalytic properties of meprin β and that, interestingly, meprin β is unable to generate N-terminally truncated Aβ peptides from Swedish mutant APP (APPswe).Concluding, we propose that meprin β may be involved in the generation of N-terminally truncated Aβ2-x peptides of APP, but acts independently from BACE-1." @default.
• W2275405720 created "2016-06-24" @default.
• W2275405720 creator A5006034564 @default.
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• W2275405720 date "2016-02-19" @default.
• W2275405720 modified "2023-10-14" @default.
• W2275405720 title "Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site" @default.
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• W2275405720 cites W1900611948 @default.
• W2275405720 cites W1964273058 @default.
• W2275405720 cites W1968995509 @default.
• W2275405720 cites W1973313300 @default.
• W2275405720 cites W1979543098 @default.
• W2275405720 cites W1980825524 @default.
• W2275405720 cites W1983864928 @default.
• W2275405720 cites W1985469117 @default.
• W2275405720 cites W1985919387 @default.
• W2275405720 cites W1993426606 @default.
• W2275405720 cites W2001870435 @default.
• W2275405720 cites W2003283600 @default.
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• W2275405720 cites W2009364039 @default.
• W2275405720 cites W2009655341 @default.
• W2275405720 cites W2010746038 @default.
• W2275405720 cites W2011303819 @default.
• W2275405720 cites W2015830307 @default.
• W2275405720 cites W2023274935 @default.
• W2275405720 cites W2024866120 @default.
• W2275405720 cites W2026053103 @default.
• W2275405720 cites W2027693753 @default.
• W2275405720 cites W2029214965 @default.
• W2275405720 cites W2029759678 @default.
• W2275405720 cites W2031231593 @default.
• W2275405720 cites W2035480642 @default.
• W2275405720 cites W2035553534 @default.
• W2275405720 cites W2036465442 @default.
• W2275405720 cites W2038012168 @default.
• W2275405720 cites W2039239447 @default.
• W2275405720 cites W2040170596 @default.
• W2275405720 cites W2040732053 @default.
• W2275405720 cites W2043413606 @default.
• W2275405720 cites W2046847750 @default.
• W2275405720 cites W2056181922 @default.
• W2275405720 cites W2056790763 @default.
• W2275405720 cites W2058110454 @default.
• W2275405720 cites W2062283435 @default.
• W2275405720 cites W2067377951 @default.
• W2275405720 cites W2071691905 @default.
• W2275405720 cites W2076309706 @default.
• W2275405720 cites W2080592458 @default.
• W2275405720 cites W2082429191 @default.
• W2275405720 cites W2088881960 @default.
• W2275405720 cites W2088989293 @default.
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• W2275405720 cites W2096410114 @default.
• W2275405720 cites W2097750046 @default.
• W2275405720 cites W2101100934 @default.
• W2275405720 cites W2110131387 @default.
• W2275405720 cites W2113690827 @default.
• W2275405720 cites W2123000765 @default.
• W2275405720 cites W2123941817 @default.
• W2275405720 cites W2130534256 @default.
• W2275405720 cites W2132810311 @default.
• W2275405720 cites W2133019124 @default.
• W2275405720 cites W2133360097 @default.
• W2275405720 cites W2137592631 @default.
• W2275405720 cites W2142807222 @default.
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• W2275405720 doi "https://doi.org/10.1186/s13024-016-0084-5" @default.
• W2275405720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759862" @default.
• W2275405720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26895626" @default.
• W2275405720 hasPublicationYear "2016" @default.
• W2275405720 type Work @default.
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