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• W2275444767 abstract "Background: For quantitative bioanalysis utilizing MS, the instrument of choice is typically a triple quadruple mass spectrometer. However, advances in high-resolution MS have allowed sensitivity and dynamic ranges to approach that of triple quadrupole instruments. Results: A matrix-free protein digest, a digested therapeutic protein and the intact peptide therapeutic liraglutide were each analyzed on high-resolution and triple quadrupole mass spectrometers with data compared. Samples from a mouse PK study with liraglutide were analyzed using the two different instruments, and equivalent PK exposure data were demonstrated. Conclusion: High-resolution and triple quadrupole mass spectrometers can generate data resulting in identical PK parameters from an in-life sample set, thus giving confidence in either technique in support of biotherapeutic PK exposure studies." @default.
• W2275444767 created "2016-06-24" @default.
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• W2275444767 date "2016-02-01" @default.
• W2275444767 modified "2023-09-25" @default.
• W2275444767 title "Application of high-resolution MS for development of peptide and large-molecule drug candidates" @default.
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• W2275444767 doi "https://doi.org/10.4155/bio.15.249" @default.
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