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- W2275459794 abstract "In the next 5–10 years we could see cellular-based pharmaceuticals, or cell therapy, meeting the unmet medical needs of thousands of people. How this therapy will meet these needs depends on the ability of researchers and manufacturers to successfully and cost effectively manufacture and deliver engineered cell-based therapeutic products that are safe and exhibit enhanced potency with resulting durable, meaningful clinical efficacy. The ability to engineer such enhanced potency using nonviral, cGMP-compliant, automated and closed system manufacturing processes will represent a significant advantage. To outline how such a process might work, we have summarized the application of a scalable, cGMP-compliant, electroporation platform for engineering dendritic cells (DCs), NK cells and T cells for development of cellular immunotherapies targeting hematological malignancies and solid tumors. Autologous cellular immunotherapy refers to a class of therapies that are designed to stimulate a specific immune respons..." @default.
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- W2275459794 date "2015-11-01" @default.
- W2275459794 modified "2023-09-27" @default.
- W2275459794 title "Development of ‘enhanced’ potency immunotherapy products using nonviral approaches" @default.
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- W2275459794 doi "https://doi.org/10.4155/pbp.15.24" @default.
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