Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275485448> ?p ?o ?g. }
- W2275485448 endingPage "12" @default.
- W2275485448 startingPage "5" @default.
- W2275485448 abstract "ObjectivesCD4+Foxp3+ regulatory T-cells (Treg) are known to accumulate under certain pathological conditions. This study was conducted to evaluate the characteristics of and dynamic changes in Treg cells in chronic hepatitis C (CHC) patients during antiviral therapy.MethodsOne hundred and forty-five subjects were enrolled in this study, including 105 CHC patients and 40 healthy donors. The phenotypes and functions of Treg cells were analyzed by flow cytometry.ResultsA significant elevation in Treg cells was observed in the peripheral blood of CHC patients compared with healthy donors. Interestingly, compared with non-suppressive Treg (non-Treg) and resting Treg (rTreg) cells, activated Treg (aTreg) cells expressed higher levels of ectonucleotidase, CD39, and CD73. After treatment with interferon alpha (IFN-α) and ribavirin (RBV) in vitro, the frequencies of total Treg cells and aTreg cells in peripheral blood mononuclear cells (PBMC), as well as the levels of transforming growth factor beta (TGF-β) secreted by aTreg and non-Treg cells, were significantly decreased. Importantly, it was found that levels of aTreg cells in patients with a sustained virological response (SVR) were lower than in relapsed patients, suggesting that a high frequency of aTreg cells might be associated with a poor clinical outcome in HCV infection.ConclusionThese results demonstrate a decreasing trend in aTreg cells, which express higher levels of CD39, CD73, and TGF-β, in SVR patients during antiviral therapy." @default.
- W2275485448 created "2016-06-24" @default.
- W2275485448 creator A5011215679 @default.
- W2275485448 creator A5023364371 @default.
- W2275485448 creator A5028313889 @default.
- W2275485448 creator A5036726873 @default.
- W2275485448 creator A5045839676 @default.
- W2275485448 creator A5046881277 @default.
- W2275485448 creator A5055411746 @default.
- W2275485448 creator A5060091977 @default.
- W2275485448 creator A5078598425 @default.
- W2275485448 creator A5083588367 @default.
- W2275485448 date "2016-04-01" @default.
- W2275485448 modified "2023-10-03" @default.
- W2275485448 title "Dynamic changes in CD45RA−Foxp3high regulatory T-cells in chronic hepatitis C patients during antiviral therapy" @default.
- W2275485448 cites W1493150347 @default.
- W2275485448 cites W1500536957 @default.
- W2275485448 cites W1568069191 @default.
- W2275485448 cites W1572895514 @default.
- W2275485448 cites W1906804363 @default.
- W2275485448 cites W1967113037 @default.
- W2275485448 cites W1971494017 @default.
- W2275485448 cites W1975753196 @default.
- W2275485448 cites W1976347185 @default.
- W2275485448 cites W1978041599 @default.
- W2275485448 cites W1979214273 @default.
- W2275485448 cites W1982054050 @default.
- W2275485448 cites W1992541741 @default.
- W2275485448 cites W2002726823 @default.
- W2275485448 cites W2004708987 @default.
- W2275485448 cites W2006882008 @default.
- W2275485448 cites W2007588559 @default.
- W2275485448 cites W2007666820 @default.
- W2275485448 cites W2011500811 @default.
- W2275485448 cites W2013696122 @default.
- W2275485448 cites W2021094135 @default.
- W2275485448 cites W2023325693 @default.
- W2275485448 cites W2027919038 @default.
- W2275485448 cites W2037648619 @default.
- W2275485448 cites W2037999529 @default.
- W2275485448 cites W2038847283 @default.
- W2275485448 cites W2039361986 @default.
- W2275485448 cites W2057925858 @default.
- W2275485448 cites W2058934410 @default.
- W2275485448 cites W2073503439 @default.
- W2275485448 cites W2077940506 @default.
- W2275485448 cites W2089882352 @default.
- W2275485448 cites W2090682694 @default.
- W2275485448 cites W2091945527 @default.
- W2275485448 cites W2110455055 @default.
- W2275485448 cites W2143454433 @default.
- W2275485448 cites W2147652122 @default.
- W2275485448 cites W2148538820 @default.
- W2275485448 cites W2164107793 @default.
- W2275485448 cites W2165305306 @default.
- W2275485448 cites W2166166447 @default.
- W2275485448 cites W2167088634 @default.
- W2275485448 cites W2169859344 @default.
- W2275485448 doi "https://doi.org/10.1016/j.ijid.2016.02.006" @default.
- W2275485448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26875600" @default.
- W2275485448 hasPublicationYear "2016" @default.
- W2275485448 type Work @default.
- W2275485448 sameAs 2275485448 @default.
- W2275485448 citedByCount "6" @default.
- W2275485448 countsByYear W22754854482020 @default.
- W2275485448 countsByYear W22754854482021 @default.
- W2275485448 countsByYear W22754854482022 @default.
- W2275485448 countsByYear W22754854482023 @default.
- W2275485448 crossrefType "journal-article" @default.
- W2275485448 hasAuthorship W2275485448A5011215679 @default.
- W2275485448 hasAuthorship W2275485448A5023364371 @default.
- W2275485448 hasAuthorship W2275485448A5028313889 @default.
- W2275485448 hasAuthorship W2275485448A5036726873 @default.
- W2275485448 hasAuthorship W2275485448A5045839676 @default.
- W2275485448 hasAuthorship W2275485448A5046881277 @default.
- W2275485448 hasAuthorship W2275485448A5055411746 @default.
- W2275485448 hasAuthorship W2275485448A5060091977 @default.
- W2275485448 hasAuthorship W2275485448A5078598425 @default.
- W2275485448 hasAuthorship W2275485448A5083588367 @default.
- W2275485448 hasBestOaLocation W22754854481 @default.
- W2275485448 hasConcept C137061746 @default.
- W2275485448 hasConcept C202751555 @default.
- W2275485448 hasConcept C203014093 @default.
- W2275485448 hasConcept C2522874641 @default.
- W2275485448 hasConcept C2776090121 @default.
- W2275485448 hasConcept C2776408679 @default.
- W2275485448 hasConcept C2778296632 @default.
- W2275485448 hasConcept C2779727006 @default.
- W2275485448 hasConcept C2780040827 @default.
- W2275485448 hasConcept C3020684253 @default.
- W2275485448 hasConcept C553184892 @default.
- W2275485448 hasConcept C55493867 @default.
- W2275485448 hasConcept C71924100 @default.
- W2275485448 hasConcept C79484868 @default.
- W2275485448 hasConcept C86803240 @default.
- W2275485448 hasConcept C8891405 @default.
- W2275485448 hasConceptScore W2275485448C137061746 @default.
- W2275485448 hasConceptScore W2275485448C202751555 @default.