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- W2275574775 abstract "The removal of methyl groups from thioethers to yield formaldehyde and free thiols by rat liver microsomal enzymes has been demonstrated. S-Demethylation requires NADP, glucose-6-phosphate, Mg++, nicotinamide, oxygen, microsomes and a soluble NADPH-generating system. NAD does not substitute for NADP. This reaction occurs predominantly in liver, but also to a very small extent in kidney and spleen. A variety of compounds of the type R—S—CH3 are S-demethylated, including compounds in which R is a purine, hydrogen, a barbiturate, benzothiazole, an amino acid and an amidine. Rat, rabbit, and mouse liver preparations demethylated 6-methylthiopurine and methylthiopseudourea, but to different degrees suggesting more than one S-demethylating enzyme. There was no significant difference in S-demethylation between male and female rats." @default.
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- W2275574775 date "1964-01-01" @default.
- W2275574775 modified "2023-09-23" @default.
- W2275574775 title "S-DEMETHYLATION BY MICROSOMAL ENZYMES." @default.
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