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- W2275584744 abstract "The microenvironment surrounding cells influences gene expression, such that a cell's behavior is largely determined by its interactions with the extracellular matrix, neighboring cells, and soluble cues released locally or by distant tissues. We describe the essential role of context and organ structure in directing mammary gland development and differentiated function, and in determining response to oncogenic insults including mutations. We expand on the concept of 'dynamic reciprocity' to present an integrated view of development, cancer, and aging, and posit that genes are like piano keys: while essential, it is the context that makes the music." @default.
- W2275584744 created "2016-06-24" @default.
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- W2275584744 date "2006-03-09" @default.
- W2275584744 modified "2023-09-27" @default.
- W2275584744 title "Of extracellular matrix, scaffolds, and signaling: Tissuearchitectureregulates development, homeostasis, and cancer" @default.
- W2275584744 hasPublicationYear "2006" @default.
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