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- W2275596189 abstract "Metabotropic glutamate receptors (mGluRs) regulate many processes in the central nervous system (CNS), including synaptic plasticity, learning, memory, motor coordination, pain transmission and neurodegeneration (Linden et al., 1991; Nicoletti et al., 1996; Conn and Pin, 1997). They form a family of eight subtypes classified into three groups, I through III (Masu et al., 1991; Houamed et al., 1991; Nakanishi, 1992; Knopfel et al., 1995; Conn and Pin, 1997), which are implicated in different aspects of physiology and pathology of the CNS: group 1 (mGluRs land 5) are mainly localized on post-synaptic membranes and are coupled to intracellular calcium pools and to membrane ion channelsviaG-proteins, whereas group II and III are localized pre-synaptically and negatively coupled to adenylate cyclase (Pin and Duvoisin, 1992). The group I mGluRs generate slow EPSPs and calcium responses in cerebellar Purkinje neurons (Batchelor and Garthwaite, 1997) and hippocampal pyramidal neurons (Congar et al., 1997). Transient mGluR-mediated calcium increases can be elicited by stimulation of IP3sensitive (Murphy and Miller, 1989, Takechi et al., 1998) and/or ryanodine-sensitive (Berridge, 1998) receptors localized on intracellular calcium stores A family of proteins has been recently described, whose expression is driven by synaptic activity (Brackeman et al., 1997), as a physical link between mGluRs and either IP3—sensitive or ryanodinesensitive receptors, termed Homer protein (Brakeman et al., 1997, Tu et al., 1998) and this represents a novel mechanism in calcium signaling and might provide molecular insight into the synaptic function of Homer proteins." @default.
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- W2275596189 date "2002-01-01" @default.
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- W2275596189 title "New Insights Into mGluRs Function in the Substantia Nigra Pars Compacta" @default.
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