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- W2275602992 abstract "Latest data are reassuring about pancreatic cancer, less so about heart failureThe incretin based drugs (dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 receptor agonists) are one of several options for glucose lowering in people with type 2 diabetes who are already taking (or unable to take) metformin.1 As with other antidiabetic drugs, the long term safety of these drugs remains unclear. Studies by Azoulay and colleagues (doi:10.1136/bmj.i581) and Li and colleagues (doi:10.1136/bmj.i610) in this issue provide updated evidence about incretin based treatments and the risk of pancreatic cancer and heart failure.2 3In 2013 the Food and Drug Administration and European Medicines Agency undertook investigations of the possible link between incretin based treatments and pancreatic cancer owing to post-marketing reports suggesting higher rates of pancreatic cancer with these drugs,4 and a study suggesting abnormal pancreatic histology among users of incretin drugs versus non-users.5 These investigations revealed no clear causal role …" @default.
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- W2275602992 date "2016-02-17" @default.
- W2275602992 modified "2023-09-27" @default.
- W2275602992 title "The safety of incretin based drug treatments for type 2 diabetes" @default.
- W2275602992 doi "https://doi.org/10.1136/bmj.i801" @default.
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