Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275654570> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2275654570 endingPage "150" @default.
- W2275654570 startingPage "144" @default.
- W2275654570 abstract "젤란검은 천연재료로써 내열성, 내산성, 내효소성 등이 우수하여 용도가 광범위하나 기계적 강도가 약하다는 단점이 있다. 따라서 본 연구에서는 기계적 성질을 개선하고자 젤란검 스폰지에 PLGA 미립구를 혼합하였다. PLGA 미립구의 다양한 함량의 젤란검 스폰지는 기계적 강도를 알아보고자 압축강도를 측정하였고, MTT 분석, SEM, 생체활성조직학적 평가 및 RT-PCR을 통해 세포의 증식 및 ECM 분비 효과를 확인하였다. 그 결과, PLGA 미립구가 50% 함유된 젤란검 지지체에서 섬유륜세포의 꾸준한 증식과 세포외기질 분비가 우수한 것을 확인할 수 있었다. 이 연구를 통하여 PLGA 미립구가 함유된 젤란검이 디스크조직 재건을 위한 지지체로서 적합함을 알 수 있었으며, 젤란검의 다양한 응용가능성을 제시하였다. Gellan gum as a natural polysaccharide has good heat resistance, acid resistance and enzymes resistance. However, one of the drawbacks of gellan gum might be the lower mechanical strength. In this work, gellan gum scaffolds were mixed with poly(lactic-co-glycolic acid) (PLGA) microsphere in order to improve mechanical properties. The gellan gum scaffolds with various contents of PLGA microsphere were prepared for the regeneration of disc tissues. To evaluate the mechanical strength of hybrid structure of gellan gum and PLGA microsphere, compression strength of the fabricated scaffolds was measured. MTT analysis, SEM observation, histological evaluation and RT-PCR were performed to confirm the effect on the cell growth and extracellular matrix secretion. As a result, it showed the best cell proliferation and extracellular matrix secretion in gellan gum sponge containing 50% PLGA microspheres. In conclusion, this study confirmed that the hybrid structure of gellan gum and PLGA microspheres was found suitable in regeneration of the intervertebral disc." @default.
- W2275654570 created "2016-06-24" @default.
- W2275654570 creator A5001453032 @default.
- W2275654570 creator A5011123230 @default.
- W2275654570 creator A5021185714 @default.
- W2275654570 creator A5029640838 @default.
- W2275654570 creator A5039258281 @default.
- W2275654570 date "2015-01-25" @default.
- W2275654570 modified "2023-10-16" @default.
- W2275654570 title "Regeneration of Intervertebral Disc Using Gellan Sponge Loading PLGA Microspheres" @default.
- W2275654570 cites W1969083496 @default.
- W2275654570 cites W1975395735 @default.
- W2275654570 cites W1978852166 @default.
- W2275654570 cites W1984595878 @default.
- W2275654570 cites W1990249097 @default.
- W2275654570 cites W1997528102 @default.
- W2275654570 cites W2003720887 @default.
- W2275654570 cites W2004573265 @default.
- W2275654570 cites W2005403551 @default.
- W2275654570 cites W2015694728 @default.
- W2275654570 cites W2019380538 @default.
- W2275654570 cites W2031770498 @default.
- W2275654570 cites W2044491176 @default.
- W2275654570 cites W2052634646 @default.
- W2275654570 cites W2057094501 @default.
- W2275654570 cites W2057251687 @default.
- W2275654570 cites W2073583505 @default.
- W2275654570 cites W2083220064 @default.
- W2275654570 cites W2084193973 @default.
- W2275654570 cites W2109496182 @default.
- W2275654570 cites W2121819403 @default.
- W2275654570 cites W2135527615 @default.
- W2275654570 cites W2148468145 @default.
- W2275654570 cites W2148495041 @default.
- W2275654570 cites W2152851858 @default.
- W2275654570 cites W2161515689 @default.
- W2275654570 cites W2170280588 @default.
- W2275654570 doi "https://doi.org/10.7317/pk.2015.39.1.144" @default.
- W2275654570 hasPublicationYear "2015" @default.
- W2275654570 type Work @default.
- W2275654570 sameAs 2275654570 @default.
- W2275654570 citedByCount "2" @default.
- W2275654570 countsByYear W22756545702015 @default.
- W2275654570 countsByYear W22756545702022 @default.
- W2275654570 crossrefType "journal-article" @default.
- W2275654570 hasAuthorship W2275654570A5001453032 @default.
- W2275654570 hasAuthorship W2275654570A5011123230 @default.
- W2275654570 hasAuthorship W2275654570A5021185714 @default.
- W2275654570 hasAuthorship W2275654570A5029640838 @default.
- W2275654570 hasAuthorship W2275654570A5039258281 @default.
- W2275654570 hasConcept C136229726 @default.
- W2275654570 hasConcept C155672457 @default.
- W2275654570 hasConcept C171250308 @default.
- W2275654570 hasConcept C185592680 @default.
- W2275654570 hasConcept C189165786 @default.
- W2275654570 hasConcept C192562407 @default.
- W2275654570 hasConcept C2780165375 @default.
- W2275654570 hasConcept C2781220964 @default.
- W2275654570 hasConcept C31903555 @default.
- W2275654570 hasConcept C55493867 @default.
- W2275654570 hasConcept C71924100 @default.
- W2275654570 hasConceptScore W2275654570C136229726 @default.
- W2275654570 hasConceptScore W2275654570C155672457 @default.
- W2275654570 hasConceptScore W2275654570C171250308 @default.
- W2275654570 hasConceptScore W2275654570C185592680 @default.
- W2275654570 hasConceptScore W2275654570C189165786 @default.
- W2275654570 hasConceptScore W2275654570C192562407 @default.
- W2275654570 hasConceptScore W2275654570C2780165375 @default.
- W2275654570 hasConceptScore W2275654570C2781220964 @default.
- W2275654570 hasConceptScore W2275654570C31903555 @default.
- W2275654570 hasConceptScore W2275654570C55493867 @default.
- W2275654570 hasConceptScore W2275654570C71924100 @default.
- W2275654570 hasIssue "1" @default.
- W2275654570 hasLocation W22756545701 @default.
- W2275654570 hasOpenAccess W2275654570 @default.
- W2275654570 hasPrimaryLocation W22756545701 @default.
- W2275654570 hasRelatedWork W1128887588 @default.
- W2275654570 hasRelatedWork W1990249097 @default.
- W2275654570 hasRelatedWork W2052634646 @default.
- W2275654570 hasRelatedWork W2058425110 @default.
- W2275654570 hasRelatedWork W2101661569 @default.
- W2275654570 hasRelatedWork W2137089152 @default.
- W2275654570 hasRelatedWork W2899084033 @default.
- W2275654570 hasRelatedWork W2945778846 @default.
- W2275654570 hasRelatedWork W2955967127 @default.
- W2275654570 hasRelatedWork W3163350643 @default.
- W2275654570 hasVolume "39" @default.
- W2275654570 isParatext "false" @default.
- W2275654570 isRetracted "false" @default.
- W2275654570 magId "2275654570" @default.
- W2275654570 workType "article" @default.