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- W2275679828 abstract "One hundred and eight vaccine-derived strains of types 1, 2, and 3 poliovirus (25 PV1, 34 PV2, and 48 PV3) isolated in Belarus in 1960-1999 were analyzed by double restriction fragment length polymorphism assay (RFLP-1, -3D1). Forty-four (40.7%) of strains were genetically modified. Eight (7.4%) PV were modified by mutation, 16 (14.8%) by recombination, and 20 (18.5%) by both mutation and recombination. The genomes of 16 PV were analyzed by multiple RFLP technique covering VP1-, VP1/VP2A-, P2-, 3AC-, and 3D1-coding regions. The majority of recombinants were simple (with one crossing over site). One strain was double recombinant (two crossings over sites) and one more multiple recombinant (three crossing over sites). Partial nucleotide sequencing of some recombinant strains showed that the degree of these strains' divergence was less than 1% in comparison with the original vaccine viruses." @default.
- W2275679828 created "2016-06-24" @default.
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- W2275679828 date "2002-01-01" @default.
- W2275679828 modified "2023-09-23" @default.
- W2275679828 title "[Mutation and recombination variability of vaccine polioviruses isolated in Belarus (1960-1999)]." @default.
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