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- W2275681757 abstract "Cross-sectional relationships were examined between regional brain volumes and mitochondrial DNA (mtDNA) 8-hydroxy-2-deoxyguanosine (8-oxo-dG) in peripheral blood mononuclear cells (PBMCs) of 47 HIV patients [mean age 51years; 81% with HIV RNA ≤50copies/mL] on combination antiretroviral therapy. The gene-specific DNA damage and repair assay measured mtDNA 8-oxo-dG break frequency. Magnetic resonance imaging was performed at 3T. Higher mtDNA 8-oxo-dG was associated with lateral ventricular enlargement and with decreased volumes of hippocampus, pallidum, and total subcortical gray matter, suggesting the involvement of systemic mitochondrial-specific oxidative stress in chronic HIV-related structural brain changes and cognitive difficulties. Clarification of the mechanism may provide potential therapeutic targets." @default.
- W2275681757 created "2016-06-24" @default.
- W2275681757 creator A5000604059 @default.
- W2275681757 creator A5024112308 @default.
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- W2275681757 creator A5068589340 @default.
- W2275681757 creator A5072086085 @default.
- W2275681757 creator A5087696598 @default.
- W2275681757 date "2016-05-01" @default.
- W2275681757 modified "2023-10-07" @default.
- W2275681757 title "Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients" @default.
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