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• W2275708029 abstract "The mammalian small intestine expresses three members of the fatty acid binding protein family; Fabp1, Fabp2, and Fabp6 that differ in their spatial expression pattern and ligand binding preference. In vitro studies using recombinant FABPs suggest an important role in lipid uptake and intestinal lipid metabolism, although the in vivo functions remain unclear. Mice genetically altered to lack Fabp2 exhibit a sex-dimorphic response to high fat diet feeding featuring weight gain and fatty liver in males but not females, suggesting that Fabp2 is involved in a sex-dimorphic intestinal metabolic program. We developed a technique for the analysis of sex differences in transcriptome data and applied it to a study of the intestinal transcriptome of chow-fed Fabp2-/- mice. This analysis revealed lipid metabolic pathways that are differentially regulated in male and female Fabp2-/- mice. We next conducted a high fat diet feeding study for the purpose of analyzing the effects of Fabp2 loss on lipid uptake capacity and spatial expression patterns of lipid metabolic genes identified from the transcriptome experiment. Females lacking Fabp2 exhibited an increased capacity for lipid uptake and an increased abundance of Fabp1 mRNA in the proximal intestine. Loss of Fabp2 also caused an increased excretion of total lipids in females compared to males. This suggests that females might be protected from the adverse effects of Fabp2 loss by directing excess lipids towards excretion pathways through an intracellular, Fabp1-mediated mechanism.%%%%Trois membres de la famille des proteines liantes d'acides gras sont exprimes dans le petit intestin des mammiferes, soit le Fabp1, Fabp2 et Fabp6. Ils different par leur structuration expressive spatiale et leur affinite de ligand. Des etudes in vitro par recombinaison genetique suggerent que les FABPs jouent un role important dans l'assimilation et le metabolisme intestinal de lipide mais leurs fonctions in vivo restent incertaines par contre. Des souris deficientes de Fabp2 par manipulations genetiques repondent differemment selon leur sexe lorsque soumissent a une diete riche en lipide de maniere que les mâles subissent un gain de poids et acquierent une hyperlipidemie du foie qui sont absents chez les femelles suggerant que le fabp2 est implique dans un programme metabolique intestinal dimorphe base sur le sexe. Nous avons elabore une technique d'analyse de donnees de transcriptome pour determiner la difference sexuelle du transcriptome intestinal de la souris Fabp2-/- nourri de moule. Cette analyse revela que la regularisation de la voie metabolique de lipides des souris mâles differe des femelles. Nous avons poursuivis avec une etude utilisant une diete a forte teneur en lipide dans le but d'analyser l'effet sur la capacite d'assimilation de lipide et la structuration expressive spatiale des genes du metabolisme des lipides, identifies par l'analyse de transcriptome precedente, par la perte de Fabp2. Les femelles deficientes de Fabp2 demontrent une augmentation de la capacite d'assimiler…" @default.
• W2275708029 created "2016-06-24" @default.
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• W2275708029 date "2012-01-01" @default.
• W2275708029 modified "2023-09-26" @default.
• W2275708029 title "Sex differences in the intestinal transcriptome and spatial patterns of lipid uptake capacity and intestinal lipid-metabolic gene expression" @default.
• W2275708029 hasPublicationYear "2012" @default.
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