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- W227574205 abstract "has been studied in several in vivo rodent assays}-9 However, the uncertainties associated with scaling up animal data to humans limit the utility of these data for the purposes of setting site-specific soil cleanup goals, In addition, bioavailability is largely governed by the physical and chemical properties ofthe soil (e.g., organic content, particle size distribution, etc.), so results may differ substantially from those used in the published studies.- Furthermore, differences in the soil PCDD/F concentrations an the presence of co-contaminants may influence bioavailability and confound the interpretation of th results.' Accordingly, for the purposes of setting site-specific soil cleanup goals for PCDDs/Fs, t collection of site-specific bioavailability data that are relevant to human exposures offers,; sever advantages over the published literature, particularly if the data can be collected in a cost-effective an relatively simple manner.10 0 In this paper, we describe an in vitro extraction test for determining the percent of PCDDs/Fs in ,s that may be liberated or solubilized in the human gastrointestinal tract, and therefore available r. absorption (i.e., the bioaccessible fraction). A test of this type has been used to assess _t bioaccessibility of various heavy metals in soils, and has been demonstrated 'to correlate with reSu from animal studies of lead bioavailability in soil. IO" @default.
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- W227574205 date "2001-01-01" @default.
- W227574205 modified "2023-09-26" @default.
- W227574205 title "IN VITRO BIOACCESSIBILITY STUDY OF LOW CONCENTRATIONS (50 350 ppt TEQ) OF DIOXINIFURANS IN WEATHERED SOILS" @default.
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