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- W2275762008 abstract "cially the case given the large doses per fraction and the tight margins around the prostate. Bladder and rectal filling plays an important part in controlling the accuracy of a patient’s setup and therefore the overall toxicities and outcomes. The aim of this study is to establish the value of characterizing a patient’s bladder filling kinetics at the time of simulation with ultrasound scans, so that a predictive model can be used to ensure a bladder volume at treatment match those at simulation. Daily bladder volume will be compared with the bladder volume in simulation. Method/Process: A prospective trial was conducted at our cancer centre in high tier intermediate risk prostate cancer patients with 25Gy in 5 fractions. Thirty patients (n1⁄430) were enrolled in this study. Patients were required to void before simulation, and then were given 150 ml of fluids to drink. Ultrasound measurements of the bladder were documented at 10 minute intervals for up to 4 measurements, with the last measurement occurring just prior to simulation. On the treatment unit, patients were requested to void at each fraction and then drink 150 ml of liquid. The kinetic model was then used to predict the optimal time to set the patient up for treatment such that the bladder volume at treatment would match that at simulation. The patient then had a Cone Beam Computed Tomography (CBCT) prior to each fraction to ensure accurate patient positioning before dose delivery. Bladder volumes at treatment were measured on the CBCT datasets using MIMVISTA software and the bladder volumes at simulation. Results/Benefits/Challenges: An average of 4 CBCT scans were conducted on each patient (2 pre-, 1 intraand 1 postCBCT). Preliminary review of the data (10/30 patients) indicated that for most patients (approximately 90%), this method of bladder preparation decreased the number of CBCT registrations and improved accuracy of prostate positioning. Process risks identified within the study were: time to conduct the scans, access to a space to perform pre-treatment ultrasound measurements and increased treatment unit time allocation. Conclusion/Impact/Outcomes: SABR for prostate requires higher levels of prostate positioning accuracy compared to conventional XRT. Patient specific bladder kinetics characterization has the potential to improve the reproducibility and accuracy of prostate setups." @default.
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- W2275762008 date "2016-03-01" @default.
- W2275762008 modified "2023-09-25" @default.
- W2275762008 title "Moving Beyond the Framed Approach in the Treatment of Stereotactic Radiosurgery" @default.
- W2275762008 doi "https://doi.org/10.1016/j.jmir.2015.12.033" @default.
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