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• W2275790165 abstract "Hematological malignancies (HM) are a public health problem. The pattern and distribution of diagnosed hematological cancers vary depending on age, sex, geography, and ethnicity suggesting the involvement of genetic and environmental factors for the development of these diseases. To our knowledge, there is no published report on HM in the case of Eastern Morocco. In this report we present for the first time the overall pattern of HM for this region. Retrospective descriptive study of patients diagnosed with HM between January 2008 and December 2012 in three centres in Eastern Morocco providing cancer diagnosis, treatment or palliative care services. The FAB (French-American-British) classification system has been taken into account in the analysis of myeloid and lymphoid neoplasms. In this study, a total of 660 cases of HM were registered between January 2008 and December 2012. Overall, 6075 cases of cancers all sites combined were registered during this study period, indicating that HM account for around 10.9 % (660/6075) of all cancers recorded. Among the 660 registered cases of HM, 53 % were males and 47 % were females, with a male to female ratio of 1.1. Thus, overall, men are slightly more affected with HM than women. By contrast, a female predominance was observed in the case of Hodgkin’s lymphoma (HL), myeloproliferative neoplasms (MPN), acute myeloid leukemia (AML) and the myelodysplastic syndrome (MDS). HM occur at a relatively young age, with an overall median age at diagnosis of 54 years. Non-Hodgkin’s lymphoma (NHL) was the most common HM accounting for 29.7 % of all HM, followed by HL, MPN, multiple myelomas (MM), chronic lymphocytic leukemia (CLL), AML, MDS, acute lymphoblastic leukemia (ALL), and Waldenström macroglobulinemia (WM). The majority of HM cases have been observed among patients aged 60 years and over (40.4 % of HM). Among this age group, NHL was the most common HM. In adolescents, HL was the most frequent HM. This study provided for the first time the pattern and distribution of HM in Eastern Morocco. Our findings justify the need to establish a regional cancer registry as a first step in blood cancer control in Eastern Morocco." @default.
• W2275790165 created "2016-06-24" @default.
• W2275790165 creator A5024490042 @default.
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• W2275790165 creator A5085120958 @default.
• W2275790165 date "2016-02-25" @default.
• W2275790165 modified "2023-09-27" @default.
• W2275790165 title "Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years" @default.
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• W2275790165 doi "https://doi.org/10.1186/s12885-016-2205-5" @default.
• W2275790165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4768409" @default.
• W2275790165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26915519" @default.
• W2275790165 hasPublicationYear "2016" @default.
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