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• W2275797864 abstract "Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and condensin, play key roles in the regulation of higher-order chromosome organization. Even though SMC proteins are thought to mechanistically determine the function of the complexes, their native conformations and dynamics have remained unclear. Here, we probe the topology of Smc2-Smc4 dimers of the S. cerevisiae condensin complex with high-speed atomic force microscopy (AFM) in liquid. We show that the Smc2-Smc4 coiled coils are highly flexible polymers with a persistence length of only ∼4 nm. Moreover, we demonstrate that the SMC dimers can adopt various architectures that interconvert dynamically over time, and we find that the SMC head domains engage not only with each other, but also with the hinge domain situated at the other end of the ∼45-nm-long coiled coil. Our findings reveal structural properties that provide insights into the molecular mechanics of condensin complexes." @default.
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• W2275797864 date "2016-03-01" @default.
• W2275797864 modified "2023-10-11" @default.
• W2275797864 title "Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic" @default.
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• W2275797864 doi "https://doi.org/10.1016/j.celrep.2016.01.063" @default.
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