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• W2275798837 abstract "Abstract Context: Metabolic dysregulation underlies key metabolic risk factors—obesity, dyslipidemia, and dysglycemia. Objective: To uncover mechanistic links between metabolomic dysregulation and metabolic risk by testing metabolite associations with risk factors cross-sectionally and with risk factor changes over time. Design: Cross-sectional—discovery samples (n = 650; age, 36–69 years) from the Framingham Heart Study (FHS) and replication samples (n = 670; age, 61–76 years) from the BioImage Study, both following a factorial design sampled from high vs low strata of body mass index, lipids, and glucose. Longitudinal—FHS participants (n = 554) with 5–7 years of follow-up for risk factor changes. Setting: Observational studies. Participants: Cross-sectional samples with or without obesity, dysglycemia, and dyslipidemia, excluding prevalent cardiovascular disease and diabetes or dyslipidemia treatment. Age- and sex-matched by group. Interventions: None. Main Outcome Measure(s): Gas chromatography-mass spectrometry detected 119 plasma metabolites. Cross-sectional associations with obesity, dyslipidemia, and dysglycemia were tested in discovery, with external replication of 37 metabolites. Single- and multi-metabolite markers were tested for association with longitudinal changes in risk factors. Results: Cross-sectional metabolite associations were identified with obesity (n = 26), dyslipidemia (n = 21), and dysglycemia (n = 11) in discovery. Glutamic acid, lactic acid, and sitosterol associated with all three risk factors in meta-analysis (P &lt; 4.5 × 10−4). Metabolites associated with longitudinal risk factor changes were enriched for bioactive lipids. Multi-metabolite panels explained 2.5–15.3% of longitudinal changes in metabolic traits. Conclusions: Cross-sectional results implicated dysregulated glutamate cycling and amino acid metabolism in metabolic risk. Certain bioactive lipids were associated with risk factors cross-sectionally and over time, suggesting their upstream role in risk factor progression. Functional studies are needed to validate findings and facilitate translation into treatments or preventive measures." @default.
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• W2275798837 date "2016-04-01" @default.
• W2275798837 modified "2023-10-10" @default.
• W2275798837 title "Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes" @default.
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• W2275798837 cites W1971124812 @default.
• W2275798837 cites W1974770153 @default.
• W2275798837 cites W1986088683 @default.
• W2275798837 cites W1986349550 @default.
• W2275798837 cites W1987403971 @default.
• W2275798837 cites W1989326472 @default.
• W2275798837 cites W1997989669 @default.
• W2275798837 cites W2000081470 @default.
• W2275798837 cites W2016082537 @default.
• W2275798837 cites W2017771330 @default.
• W2275798837 cites W2018638168 @default.
• W2275798837 cites W2022585591 @default.
• W2275798837 cites W2026202377 @default.
• W2275798837 cites W2026620576 @default.
• W2275798837 cites W2041498503 @default.
• W2275798837 cites W2044287572 @default.
• W2275798837 cites W2045781044 @default.
• W2275798837 cites W2049531465 @default.
• W2275798837 cites W2053884673 @default.
• W2275798837 cites W2057424383 @default.
• W2275798837 cites W2058006650 @default.
• W2275798837 cites W2059079984 @default.
• W2275798837 cites W2060538120 @default.
• W2275798837 cites W2063649606 @default.
• W2275798837 cites W2063922243 @default.
• W2275798837 cites W2065604182 @default.
• W2275798837 cites W2072945343 @default.
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• W2275798837 cites W207574618 @default.
• W2275798837 cites W2076025331 @default.
• W2275798837 cites W2078970313 @default.
• W2275798837 cites W2083354795 @default.
• W2275798837 cites W2083384274 @default.
• W2275798837 cites W2086175686 @default.
• W2275798837 cites W2098885807 @default.
• W2275798837 cites W2099491564 @default.
• W2275798837 cites W2100094462 @default.
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• W2275798837 cites W2101134096 @default.
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• W2275798837 cites W2122367003 @default.
• W2275798837 cites W2122482553 @default.
• W2275798837 cites W2122713183 @default.
• W2275798837 cites W2125575989 @default.
• W2275798837 cites W2135322599 @default.
• W2275798837 cites W2137448986 @default.
• W2275798837 cites W2143860368 @default.
• W2275798837 cites W2144636739 @default.
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• W2275798837 doi "https://doi.org/10.1210/jc.2015-2555" @default.
• W2275798837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4880163" @default.
• W2275798837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26908103" @default.
• W2275798837 hasPublicationYear "2016" @default.
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