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• W227580377 abstract "Research Article1 June 1992free access Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. H. König H. König Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author H. Ponta H. Ponta Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author H.J. Rahmsdorf H.J. Rahmsdorf Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author P. Herrlich P. Herrlich Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author H. König H. König Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author H. Ponta H. Ponta Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author H.J. Rahmsdorf H.J. Rahmsdorf Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author P. Herrlich P. Herrlich Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. Search for more papers by this author Author Information H. König1, H. Ponta1, H.J. Rahmsdorf1 and P. Herrlich1 1Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Germany. The EMBO Journal (1992)11:2241-2246https://doi.org/10.1002/j.1460-2075.1992.tb05283.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Phorbol esters stimulate and glucocorticoid hormones down-regulate a variety of promoters such as that of the collagenase gene through the transcription factor AP-1 (Fos/Jun). We now show by genomic footprinting of the collagenase promoter that phorbol ester treatment of cells results in the binding of AP-1 to its cognate DNA binding site in vivo. The DNA-protein contacts obtained in living cells are also found in vitro using cloned DNA and purified AP-1. Although in vitro synthesized glucocorticoid receptor can disturb the DNA binding of Jun homodimers, it does not interfere with the binding of Fos-Jun heterodimers or of purified AP-1 in vitro. Consistently, fully inhibitory doses of glucocorticoid hormone cause no change in apparent occupation of the AP-1 binding site in vivo. The hormone receptor acts without itself binding to DNA. Previous ArticleNext Article Volume 11Issue 61 June 1992In this issue RelatedDetailsLoading ..." @default.
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• W227580377 title "Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo." @default.
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