Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275876650> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2275876650 endingPage "489" @default.
- W2275876650 startingPage "481" @default.
- W2275876650 abstract "Poor early nutrition may elicit long-term detrimental effects on adult health, including susceptibility to non-insulin-dependent diabetes mellitus. We investigated the impact of moderate maternal protein restriction during pregnancy and lactation on the action of insulin on adipocyte glucose uptake in female offspring during their own pregnancies. Offspring of dams provided with diets containing either 200 g protein/kg or 80 g protein/kg during pregnancy and lactation (termed C and EPR groups respectively) were weaned on to 200 g protein/kg diet at 24 d of age. At 9–12 weeks of age both groups were time-mated and studied at day 19 of gestation. Rates of glucose utilization (assessed using the 2-deoxy-d-- [1- 3 H- ]glucose technique) measured in five distinct adipose tissue depots (parametrial (PM), mesenteric (MES), perirenal (PR), subcutaneous (SC), interscapular (IS)) in vivo in the post-absorptive state were consistently lower in early-protein-restricted (EPR) pregnant rats compared with control (C) pregnant rats. In C pregnant rats, insulin significantly increased glucose utilization only in the IS depot. In contrast, significantly increased glucose utilization rates in response to hyperinsulinaemia were evident in all five adipose-tissue depots of the EPR pregnant group. Consequently, glucose utilization rates in PM and SC depots during hyperinsulinaemia were significantly higher in EPR pregnant rats compared with C pregnant rats. Adipocytes were isolated from PM and MES depots to determine whether altered responses to insulin in vivo were retained in vitro . Rates of insulin-stimulated glucose uptake at sub-maximal (15 μU/ml) and maximal (15 mU/ml) insulin concentrations were significantly higher in both MES and PM adipocytes from EPR pregnant rats, but the sensitivity of glucose uptake to insulin at low concentrations was blunted compared with adipocytes from C pregnant rats. The results demonstrate that early protein restriction enhances the capacity for adipocyte glucose uptake at high insulin concentrations, but dampens the response to insulin at low physiological concentrations." @default.
- W2275876650 created "2016-06-24" @default.
- W2275876650 creator A5034088672 @default.
- W2275876650 creator A5047213083 @default.
- W2275876650 creator A5054274823 @default.
- W2275876650 date "1999-06-01" @default.
- W2275876650 modified "2023-09-27" @default.
- W2275876650 title "Protein restriction during early development enhances insulin responsiveness but selectively impairs sensitivity to insulin at low concentrations in white adipose tissue during a later pregnancy" @default.
- W2275876650 cites W121061212 @default.
- W2275876650 cites W1484180926 @default.
- W2275876650 cites W1626222017 @default.
- W2275876650 cites W1783890436 @default.
- W2275876650 cites W1965192265 @default.
- W2275876650 cites W1968426538 @default.
- W2275876650 cites W1974352541 @default.
- W2275876650 cites W1988851701 @default.
- W2275876650 cites W1992527366 @default.
- W2275876650 cites W2021974550 @default.
- W2275876650 cites W2040229409 @default.
- W2275876650 cites W2057538029 @default.
- W2275876650 cites W2066291819 @default.
- W2275876650 cites W2092941844 @default.
- W2275876650 cites W2108879058 @default.
- W2275876650 cites W2114469458 @default.
- W2275876650 cites W2116597622 @default.
- W2275876650 cites W2120073172 @default.
- W2275876650 cites W2128525246 @default.
- W2275876650 cites W2138959160 @default.
- W2275876650 cites W2143941188 @default.
- W2275876650 cites W458718 @default.
- W2275876650 cites W67436724 @default.
- W2275876650 cites W81610206 @default.
- W2275876650 doi "https://doi.org/10.1017/s0007114599000847" @default.
- W2275876650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10615224" @default.
- W2275876650 hasPublicationYear "1999" @default.
- W2275876650 type Work @default.
- W2275876650 sameAs 2275876650 @default.
- W2275876650 citedByCount "21" @default.
- W2275876650 countsByYear W22758766502015 @default.
- W2275876650 countsByYear W22758766502017 @default.
- W2275876650 crossrefType "journal-article" @default.
- W2275876650 hasAuthorship W2275876650A5034088672 @default.
- W2275876650 hasAuthorship W2275876650A5047213083 @default.
- W2275876650 hasAuthorship W2275876650A5054274823 @default.
- W2275876650 hasBestOaLocation W22758766501 @default.
- W2275876650 hasConcept C112672928 @default.
- W2275876650 hasConcept C126322002 @default.
- W2275876650 hasConcept C134018914 @default.
- W2275876650 hasConcept C151955695 @default.
- W2275876650 hasConcept C171089720 @default.
- W2275876650 hasConcept C2776175234 @default.
- W2275876650 hasConcept C2776659692 @default.
- W2275876650 hasConcept C2777391703 @default.
- W2275876650 hasConcept C2777866211 @default.
- W2275876650 hasConcept C2779234561 @default.
- W2275876650 hasConcept C2779306644 @default.
- W2275876650 hasConcept C2780352109 @default.
- W2275876650 hasConcept C2780988686 @default.
- W2275876650 hasConcept C54355233 @default.
- W2275876650 hasConcept C71924100 @default.
- W2275876650 hasConcept C86803240 @default.
- W2275876650 hasConceptScore W2275876650C112672928 @default.
- W2275876650 hasConceptScore W2275876650C126322002 @default.
- W2275876650 hasConceptScore W2275876650C134018914 @default.
- W2275876650 hasConceptScore W2275876650C151955695 @default.
- W2275876650 hasConceptScore W2275876650C171089720 @default.
- W2275876650 hasConceptScore W2275876650C2776175234 @default.
- W2275876650 hasConceptScore W2275876650C2776659692 @default.
- W2275876650 hasConceptScore W2275876650C2777391703 @default.
- W2275876650 hasConceptScore W2275876650C2777866211 @default.
- W2275876650 hasConceptScore W2275876650C2779234561 @default.
- W2275876650 hasConceptScore W2275876650C2779306644 @default.
- W2275876650 hasConceptScore W2275876650C2780352109 @default.
- W2275876650 hasConceptScore W2275876650C2780988686 @default.
- W2275876650 hasConceptScore W2275876650C54355233 @default.
- W2275876650 hasConceptScore W2275876650C71924100 @default.
- W2275876650 hasConceptScore W2275876650C86803240 @default.
- W2275876650 hasIssue "6" @default.
- W2275876650 hasLocation W22758766501 @default.
- W2275876650 hasLocation W22758766502 @default.
- W2275876650 hasOpenAccess W2275876650 @default.
- W2275876650 hasPrimaryLocation W22758766501 @default.
- W2275876650 hasRelatedWork W1951732046 @default.
- W2275876650 hasRelatedWork W1957106181 @default.
- W2275876650 hasRelatedWork W2017606817 @default.
- W2275876650 hasRelatedWork W2032225465 @default.
- W2275876650 hasRelatedWork W2056849036 @default.
- W2275876650 hasRelatedWork W2071032213 @default.
- W2275876650 hasRelatedWork W2079309060 @default.
- W2275876650 hasRelatedWork W2094672900 @default.
- W2275876650 hasRelatedWork W2161160210 @default.
- W2275876650 hasRelatedWork W2180861891 @default.
- W2275876650 hasVolume "81" @default.
- W2275876650 isParatext "false" @default.
- W2275876650 isRetracted "false" @default.
- W2275876650 magId "2275876650" @default.
- W2275876650 workType "article" @default.