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• W2275882583 abstract "9 1 Review of the literature 11 1.1 Discovery and Classification 11 1.1.1 Discovery of hantaviruses 11 1.1.2 Classification of hantaviruses 12 1.2 Cell biology of hantaviruses 13 1.2.1 Virion 13 1.2.2 Entry 15 1.2.3 RNA synthesis 19 1.2.4 Progeny virus formation 25 1.3 Hantavirus pathogenesis 33 1.3.1 Clinical picture of hantavirus-mediated diseases 33 1.3.2 Vascular leakage 35 1.3.3 Renal failure in NE 40 1.3.4 Innate immunity responses 41 2 Aims of the study 44 3 Materials and methods 45 3.1 Materials 45 3.1.1 Cell cultures 45 3.1.2 Viruses 45 3.1.3 Peptide synthesis 46 3.1.4 Peptide array synthesis 46 3.1.5 Protein synthesis 47 3.1.6 Nucleic acid synthesis 47 3.1.7 Antibodies 48 3.1.8 Reagents 48 3.2 Methods 49 3.2.1 Immunoblotting 49 3.2.2 Immunoprecipitation 49 3.2.3 Pull-down assays 50 3.2.4 Virus inactivation 50 3.2.5 Sedimentation analysis 51 3.2.6 Cross-linking of RNA to proteins 51 3.2.7 Probing peptide arrays 51" @default.
• W2275882583 created "2016-06-24" @default.
• W2275882583 creator A5054501795 @default.
• W2275882583 date "2011-12-16" @default.
• W2275882583 modified "2023-09-25" @default.
• W2275882583 title "Hantavirus infection: Insights into entry, assembly and pathogenesis" @default.
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