Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275888986> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2275888986 endingPage "e0134967" @default.
- W2275888986 startingPage "e0134967" @default.
- W2275888986 abstract "Immunotherapy is emerging as a supplement to conventional cancer treatment, and identifying antigen targets for specific types of cancer is critical to optimizing therapeutic efficacy. Cancer/testis antigens are highly promising targets for immunotherapy due to their cancer-specific expression and antigenic properties, but the expression patterns of most of the more than 200 identified cancer/testis antigens in various cancers remain largely uncharacterized. In this study, we investigated the expression of the cancer/testis antigens ADAM2, CALR3 and SAGE1 in lung and breast cancer, the two most frequent human cancers, with the purpose of providing novel therapeutic targets for these diseases. We used a set of previously uncharacterized antibodies against the cancer/testis antigens ADAM2, CALR3 and SAGE1 to investigate their expression in a large panel of normal tissues as well as breast and lung cancers. Staining for the well-characterized MAGE-A proteins was included for comparison. Immunohistochemical staining confirmed previous mRNA analysis demonstrating that ADAM2, CALR3 and SAGE1 proteins are confined to testis in normal individuals. Negative tissues included plancenta, which express many other CT antigens, such as MAGE-A proteins. Surprisingly, we detected no ADAM2, CALR3 and SAGE1 in the 67 lung cancers (mainly non-small lung cancer) and 189 breast cancers, while MAGE-A proteins were present in 15% and 7–16% of these tumor types, respectively. Treatment with DNA methyltransferase inhibitors has been proposed as an attractive strategy to increase the expression of cancer/testis antigens in tumors before immunotargeting; however, neither ADAM2, CALR3 nor SAGE1 could be significantly induced in lung and breast cancer cell lines using this strategy. Our results suggest that ADAM2, CALR3 and SAGE1 cancer/testis antigens are not promising targets for immunotherapy of breast and lung cancer." @default.
- W2275888986 created "2016-06-24" @default.
- W2275888986 creator A5011720560 @default.
- W2275888986 creator A5039713001 @default.
- W2275888986 creator A5078320465 @default.
- W2275888986 creator A5081406989 @default.
- W2275888986 date "2015-08-07" @default.
- W2275888986 modified "2023-10-18" @default.
- W2275888986 title "Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer" @default.
- W2275888986 cites W1598446361 @default.
- W2275888986 cites W1605109223 @default.
- W2275888986 cites W1978464071 @default.
- W2275888986 cites W1984994348 @default.
- W2275888986 cites W1985594917 @default.
- W2275888986 cites W1992324708 @default.
- W2275888986 cites W2006808166 @default.
- W2275888986 cites W2020312840 @default.
- W2275888986 cites W2030317951 @default.
- W2275888986 cites W2047303314 @default.
- W2275888986 cites W2050107549 @default.
- W2275888986 cites W2070748533 @default.
- W2275888986 cites W2074591408 @default.
- W2275888986 cites W2085208565 @default.
- W2275888986 cites W2085243878 @default.
- W2275888986 cites W2096385955 @default.
- W2275888986 cites W2131879910 @default.
- W2275888986 cites W2139229100 @default.
- W2275888986 cites W2143626441 @default.
- W2275888986 cites W2144092647 @default.
- W2275888986 cites W2155508309 @default.
- W2275888986 cites W2162894710 @default.
- W2275888986 cites W2165242935 @default.
- W2275888986 doi "https://doi.org/10.1371/journal.pone.0134967" @default.
- W2275888986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4529184" @default.
- W2275888986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26252478" @default.
- W2275888986 hasPublicationYear "2015" @default.
- W2275888986 type Work @default.
- W2275888986 sameAs 2275888986 @default.
- W2275888986 citedByCount "11" @default.
- W2275888986 countsByYear W22758889862017 @default.
- W2275888986 countsByYear W22758889862018 @default.
- W2275888986 countsByYear W22758889862021 @default.
- W2275888986 countsByYear W22758889862022 @default.
- W2275888986 countsByYear W22758889862023 @default.
- W2275888986 crossrefType "journal-article" @default.
- W2275888986 hasAuthorship W2275888986A5011720560 @default.
- W2275888986 hasAuthorship W2275888986A5039713001 @default.
- W2275888986 hasAuthorship W2275888986A5078320465 @default.
- W2275888986 hasAuthorship W2275888986A5081406989 @default.
- W2275888986 hasBestOaLocation W22758889861 @default.
- W2275888986 hasConcept C121608353 @default.
- W2275888986 hasConcept C126322002 @default.
- W2275888986 hasConcept C142724271 @default.
- W2275888986 hasConcept C147483822 @default.
- W2275888986 hasConcept C203014093 @default.
- W2275888986 hasConcept C204232928 @default.
- W2275888986 hasConcept C2776256026 @default.
- W2275888986 hasConcept C2777701055 @default.
- W2275888986 hasConcept C2780674031 @default.
- W2275888986 hasConcept C502942594 @default.
- W2275888986 hasConcept C530470458 @default.
- W2275888986 hasConcept C71924100 @default.
- W2275888986 hasConcept C86803240 @default.
- W2275888986 hasConceptScore W2275888986C121608353 @default.
- W2275888986 hasConceptScore W2275888986C126322002 @default.
- W2275888986 hasConceptScore W2275888986C142724271 @default.
- W2275888986 hasConceptScore W2275888986C147483822 @default.
- W2275888986 hasConceptScore W2275888986C203014093 @default.
- W2275888986 hasConceptScore W2275888986C204232928 @default.
- W2275888986 hasConceptScore W2275888986C2776256026 @default.
- W2275888986 hasConceptScore W2275888986C2777701055 @default.
- W2275888986 hasConceptScore W2275888986C2780674031 @default.
- W2275888986 hasConceptScore W2275888986C502942594 @default.
- W2275888986 hasConceptScore W2275888986C530470458 @default.
- W2275888986 hasConceptScore W2275888986C71924100 @default.
- W2275888986 hasConceptScore W2275888986C86803240 @default.
- W2275888986 hasIssue "8" @default.
- W2275888986 hasLocation W22758889861 @default.
- W2275888986 hasLocation W22758889862 @default.
- W2275888986 hasLocation W22758889863 @default.
- W2275888986 hasOpenAccess W2275888986 @default.
- W2275888986 hasPrimaryLocation W22758889861 @default.
- W2275888986 hasRelatedWork W1974496092 @default.
- W2275888986 hasRelatedWork W2030612376 @default.
- W2275888986 hasRelatedWork W2135979959 @default.
- W2275888986 hasRelatedWork W2755360248 @default.
- W2275888986 hasRelatedWork W2996772275 @default.
- W2275888986 hasRelatedWork W3084138469 @default.
- W2275888986 hasRelatedWork W3121641884 @default.
- W2275888986 hasRelatedWork W3127346141 @default.
- W2275888986 hasRelatedWork W4214943367 @default.
- W2275888986 hasRelatedWork W4285244024 @default.
- W2275888986 hasVolume "10" @default.
- W2275888986 isParatext "false" @default.
- W2275888986 isRetracted "false" @default.
- W2275888986 magId "2275888986" @default.
- W2275888986 workType "article" @default.