Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275896291> ?p ?o ?g. }
- W2275896291 endingPage "962" @default.
- W2275896291 startingPage "957" @default.
- W2275896291 abstract "In the present study, we investigated the effects of type 2 diabetes-induced hyperglycemia on the integrity of the blood–brain barrier and tight junction markers in the rat hippocampus. Forty-week-old diabetic (Zucker diabetic fatty, ZDF) rats and littermate control (Zucker lean control, ZLC) rats were used in this study. We evaluated the integrity of the blood–brain barrier by measuring sodium fluorescein extravasation and blood vessel ultrastructure. In addition, tight junction markers, such as zona occludens-1, occludin and claudin-5, were quantified by western blot analysis. ZDF rats showed significantly increased sodium fluorescein leakage in the hippocampus. Tight junction markers, such as occludin and claudin-5, were significantly decreased in the hippocampi of ZDF rats compared to those of ZLC rats. In addition, ZDF rats showed ultrastructural changes with phagocytic findings in the blood vessels. These results suggest that chronic untreated diabetes impairs the permeability of the hippocampal blood–brain barrier by down-regulating occludin and claudin-5, indicating that chronic untreated diabetes may cause hippocampus-dependent dysfunction." @default.
- W2275896291 created "2016-06-24" @default.
- W2275896291 creator A5002067880 @default.
- W2275896291 creator A5031878697 @default.
- W2275896291 creator A5035539418 @default.
- W2275896291 creator A5057807816 @default.
- W2275896291 creator A5062412347 @default.
- W2275896291 creator A5064111743 @default.
- W2275896291 creator A5068124881 @default.
- W2275896291 creator A5079828840 @default.
- W2275896291 creator A5083686312 @default.
- W2275896291 creator A5084338028 @default.
- W2275896291 date "2016-01-01" @default.
- W2275896291 modified "2023-09-27" @default.
- W2275896291 title "Chronic type 2 diabetes reduces the integrity of the blood-brain barrier by reducing tight junction proteins in the hippocampus" @default.
- W2275896291 cites W1558414356 @default.
- W2275896291 cites W1584384737 @default.
- W2275896291 cites W1593393815 @default.
- W2275896291 cites W1606934029 @default.
- W2275896291 cites W1630758895 @default.
- W2275896291 cites W1648931652 @default.
- W2275896291 cites W1736033689 @default.
- W2275896291 cites W1970102431 @default.
- W2275896291 cites W1972076726 @default.
- W2275896291 cites W1972448300 @default.
- W2275896291 cites W1975898995 @default.
- W2275896291 cites W1983190090 @default.
- W2275896291 cites W1983591907 @default.
- W2275896291 cites W1985772720 @default.
- W2275896291 cites W1992758695 @default.
- W2275896291 cites W1997366085 @default.
- W2275896291 cites W1999194391 @default.
- W2275896291 cites W2000829001 @default.
- W2275896291 cites W2020554150 @default.
- W2275896291 cites W2028212562 @default.
- W2275896291 cites W2031734589 @default.
- W2275896291 cites W2040509610 @default.
- W2275896291 cites W2044950493 @default.
- W2275896291 cites W2046502766 @default.
- W2275896291 cites W2068690756 @default.
- W2275896291 cites W2070225650 @default.
- W2275896291 cites W2077702165 @default.
- W2275896291 cites W2078147565 @default.
- W2275896291 cites W2088303839 @default.
- W2275896291 cites W2090789207 @default.
- W2275896291 cites W2092288357 @default.
- W2275896291 cites W2094529655 @default.
- W2275896291 cites W2103831817 @default.
- W2275896291 cites W2110930701 @default.
- W2275896291 cites W2128550469 @default.
- W2275896291 cites W2134243884 @default.
- W2275896291 cites W2141866284 @default.
- W2275896291 cites W2157103967 @default.
- W2275896291 cites W2163097079 @default.
- W2275896291 cites W2165651695 @default.
- W2275896291 cites W2319030457 @default.
- W2275896291 cites W2341041769 @default.
- W2275896291 doi "https://doi.org/10.1292/jvms.15-0589" @default.
- W2275896291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4937155" @default.
- W2275896291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26876499" @default.
- W2275896291 hasPublicationYear "2016" @default.
- W2275896291 type Work @default.
- W2275896291 sameAs 2275896291 @default.
- W2275896291 citedByCount "49" @default.
- W2275896291 countsByYear W22758962912016 @default.
- W2275896291 countsByYear W22758962912017 @default.
- W2275896291 countsByYear W22758962912018 @default.
- W2275896291 countsByYear W22758962912019 @default.
- W2275896291 countsByYear W22758962912020 @default.
- W2275896291 countsByYear W22758962912021 @default.
- W2275896291 countsByYear W22758962912022 @default.
- W2275896291 countsByYear W22758962912023 @default.
- W2275896291 crossrefType "journal-article" @default.
- W2275896291 hasAuthorship W2275896291A5002067880 @default.
- W2275896291 hasAuthorship W2275896291A5031878697 @default.
- W2275896291 hasAuthorship W2275896291A5035539418 @default.
- W2275896291 hasAuthorship W2275896291A5057807816 @default.
- W2275896291 hasAuthorship W2275896291A5062412347 @default.
- W2275896291 hasAuthorship W2275896291A5064111743 @default.
- W2275896291 hasAuthorship W2275896291A5068124881 @default.
- W2275896291 hasAuthorship W2275896291A5079828840 @default.
- W2275896291 hasAuthorship W2275896291A5083686312 @default.
- W2275896291 hasAuthorship W2275896291A5084338028 @default.
- W2275896291 hasBestOaLocation W22758962911 @default.
- W2275896291 hasConcept C104317684 @default.
- W2275896291 hasConcept C126322002 @default.
- W2275896291 hasConcept C134018914 @default.
- W2275896291 hasConcept C142724271 @default.
- W2275896291 hasConcept C148762608 @default.
- W2275896291 hasConcept C177779419 @default.
- W2275896291 hasConcept C2775962179 @default.
- W2275896291 hasConcept C2776415932 @default.
- W2275896291 hasConcept C2777180221 @default.
- W2275896291 hasConcept C2777649898 @default.
- W2275896291 hasConcept C2778402981 @default.
- W2275896291 hasConcept C2779540182 @default.
- W2275896291 hasConcept C2781161787 @default.
- W2275896291 hasConcept C529278444 @default.