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- W2275911717 abstract "Within the past years, we have witnessed a great improvement is mass spectrometry (MS) and proteomics approaches in terms of instrumentation, protein fractionation, and bioinformatics. With the current technology, protein identification alone is no longer sufficient. Both scientists and clinicians want not only to identify the proteins, but also to identify the protein's post-translational modifications (PTMs), protein isoforms, protein truncation, protein-protein interactions (PPI), and protein quantitation. Here, we describe the principle of MS and proteomics, and strategies to identify proteins, protein's PTMs, protein isoforms, protein truncation, PPIs, and protein quantitation. We also discuss the strengths and weaknesses within this field. Finally, in our concluding remarks we assess the role of mass spectrometry and proteomics in the scientific and clinical settings, in the near future. This chapter provides an introduction and overview for subsequent chapters that will discuss specific MS proteomic methodologies and their application to specific medical conditions. Other chapters will also touch upon areas that expand beyond proteomics, such as lipidomics and metabolomics." @default.
- W2275911717 created "2016-06-24" @default.
- W2275911717 creator A5016000610 @default.
- W2275911717 creator A5028707297 @default.
- W2275911717 creator A5032470535 @default.
- W2275911717 creator A5036122174 @default.
- W2275911717 creator A5046362586 @default.
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- W2275911717 creator A5059055717 @default.
- W2275911717 creator A5061437305 @default.
- W2275911717 creator A5079072427 @default.
- W2275911717 date "2019-01-01" @default.
- W2275911717 modified "2023-09-27" @default.
- W2275911717 title "Mass Spectrometry for Proteomics-Based Investigation" @default.
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