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- W2275978586 endingPage "208" @default.
- W2275978586 startingPage "193" @default.
- W2275978586 abstract "Schizophrenia is a heterogeneous, debilitating disorder characterized by three distinct sets of clinical features: positive symptoms, negative symptoms, and cognitive deficits. Extant antipsychotic drugs have been most successful at treating the positive symptoms of patients with schizophrenia but have minimal therapeutic effects on negative symptoms and cognitive deficits, which are the symptoms that best predict the poor prognosis of these patients. Therefore, there has been a major effort towards identifying compounds that alleviate these symptoms. Oxytocin (OT) is a nonapeptide that regulates peripheral reproductive-relevant functions, and also acts as a neurotransmitter in the brain. Converging evidence from both preclinical and clinical research suggests that OT may have therapeutic efficacy for the positive symptoms, negative symptoms, and cognitive deficits of schizophrenia. In the majority of the small, randomized, placebo-controlled clinical trials conducted to date, OT has shown particular promise in its potential to treat the intractable negative symptoms and social cognitive deficits exhibited by most of the patients with this debilitating disorder. In this leading article, we summarize the clinical evidence relevant to (1) endogenous OT and schizophrenia, and (2) the putative therapeutic effects of OT on each of the three clinical domains." @default.
- W2275978586 created "2016-06-24" @default.
- W2275978586 creator A5000063591 @default.
- W2275978586 creator A5085756994 @default.
- W2275978586 date "2016-02-19" @default.
- W2275978586 modified "2023-10-02" @default.
- W2275978586 title "Potential of Oxytocin in the Treatment of Schizophrenia" @default.
- W2275978586 cites W1441608289 @default.
- W2275978586 cites W1487226122 @default.
- W2275978586 cites W1495797590 @default.
- W2275978586 cites W1524976982 @default.
- W2275978586 cites W1556392272 @default.
- W2275978586 cites W1803779312 @default.
- W2275978586 cites W1879824241 @default.
- W2275978586 cites W1906182817 @default.
- W2275978586 cites W1935553043 @default.
- W2275978586 cites W1939470521 @default.
- W2275978586 cites W1947132699 @default.
- W2275978586 cites W1955310396 @default.
- W2275978586 cites W1964166984 @default.
- W2275978586 cites W1969521643 @default.
- W2275978586 cites W1970595907 @default.
- W2275978586 cites W1971271713 @default.
- W2275978586 cites W1974375338 @default.
- W2275978586 cites W1976289354 @default.
- W2275978586 cites W1976654483 @default.
- W2275978586 cites W1978371403 @default.
- W2275978586 cites W1978408267 @default.
- W2275978586 cites W1979579595 @default.
- W2275978586 cites W1981422293 @default.
- W2275978586 cites W1982063326 @default.
- W2275978586 cites W1982278776 @default.
- W2275978586 cites W1984229889 @default.
- W2275978586 cites W1987264245 @default.
- W2275978586 cites W1988209406 @default.
- W2275978586 cites W1989076745 @default.
- W2275978586 cites W1991715260 @default.
- W2275978586 cites W1996368170 @default.
- W2275978586 cites W1997981295 @default.
- W2275978586 cites W1998913705 @default.
- W2275978586 cites W1999143702 @default.
- W2275978586 cites W2000118536 @default.
- W2275978586 cites W2002360316 @default.
- W2275978586 cites W2005143013 @default.
- W2275978586 cites W2006327345 @default.
- W2275978586 cites W2006909083 @default.
- W2275978586 cites W2009984993 @default.
- W2275978586 cites W2010027976 @default.
- W2275978586 cites W2010808031 @default.
- W2275978586 cites W2012771984 @default.
- W2275978586 cites W2021214998 @default.
- W2275978586 cites W2021988264 @default.
- W2275978586 cites W2026027052 @default.
- W2275978586 cites W2026476829 @default.
- W2275978586 cites W2029827941 @default.
- W2275978586 cites W2032991174 @default.
- W2275978586 cites W2033955495 @default.
- W2275978586 cites W2035561357 @default.
- W2275978586 cites W2038181972 @default.
- W2275978586 cites W2039413967 @default.
- W2275978586 cites W2044619557 @default.
- W2275978586 cites W2044976604 @default.
- W2275978586 cites W2045659750 @default.
- W2275978586 cites W2045853313 @default.
- W2275978586 cites W2045865877 @default.
- W2275978586 cites W2046053576 @default.
- W2275978586 cites W2046432386 @default.
- W2275978586 cites W2046959837 @default.
- W2275978586 cites W2048889064 @default.
- W2275978586 cites W2050973084 @default.
- W2275978586 cites W2053192100 @default.
- W2275978586 cites W2056856182 @default.
- W2275978586 cites W2059603488 @default.
- W2275978586 cites W2060129792 @default.
- W2275978586 cites W2060342184 @default.
- W2275978586 cites W2061226698 @default.
- W2275978586 cites W2061325549 @default.
- W2275978586 cites W2065505554 @default.
- W2275978586 cites W2065752173 @default.
- W2275978586 cites W2068677067 @default.
- W2275978586 cites W2071486937 @default.
- W2275978586 cites W2076861590 @default.
- W2275978586 cites W2083000419 @default.
- W2275978586 cites W2084025375 @default.
- W2275978586 cites W2086265497 @default.
- W2275978586 cites W2087359530 @default.
- W2275978586 cites W2087362865 @default.
- W2275978586 cites W2090522879 @default.
- W2275978586 cites W2091864947 @default.
- W2275978586 cites W2092637667 @default.
- W2275978586 cites W2092870960 @default.
- W2275978586 cites W2095069422 @default.
- W2275978586 cites W2099168883 @default.
- W2275978586 cites W2100638793 @default.
- W2275978586 cites W2102027817 @default.
- W2275978586 cites W2104544266 @default.
- W2275978586 cites W2106930497 @default.
- W2275978586 cites W2109677536 @default.