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• W2275983818 startingPage "1660" @default.
• W2275983818 abstract "The G-quadruplexes located in the P1 promoter of B-cell lymphoma-2 (Bcl-2) gene are implicated to regulate Bcl-2 expression. Here, we designed a new pyridostatin analog named PDF, which exhibited high specificity and stabilizing effect toward G-quadruplexes. The luciferase assay demonstrated that PDF could significantly suppress Bcl-2 transcriptional activation in human laryngeal squamous carcinoma cells (Hep-2) cells. Besides, PDF also induced cell apoptosis in vitro assays. These results provide an excellent G-quadruplex specific ligand as an efficient Bcl-2 inhibitor. These results also implicate that PDF may be a potential anticancer drug to head neck cancer." @default.
• W2275983818 created "2016-06-24" @default.
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• W2275983818 date "2016-04-01" @default.
• W2275983818 modified "2023-09-23" @default.
• W2275983818 title "Stabilization of G-quadruplex DNA and inhibition of Bcl-2 expression by a pyridostatin analog" @default.
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• W2275983818 doi "https://doi.org/10.1016/j.bmcl.2016.02.065" @default.
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