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- W2275984853 abstract "Positron emission tomography (PET) allows non‐invasive assessment of physiological, metabolic and molecular processes in vivo. With the achievements in detector technology, spatial resolution of PET has been improved (1–2mm) enabling investigations in small experimental animals such as mice. With the development in tracer technology a variety of endogenously expressed and exogenously introduced genes can be analyzed by PET. This opens up the exciting and rapidly evolving field of molecular imaging aiming towards the non‐invasive localization of the dynamics of disease specific molecular alterations and biological processes in animal models and humans in vivo. The main and most intriguing advantage of molecular imaging is the kinetic analysis of a given molecular event in the same experimental subject over time. This allows non‐invasive characterization of animal models of human disease at various disease stages and after therapeutic intervention. Optical imaging (OI) is a non‐invasive molecular imaging technology that uses light to interrogate cellular and molecular function in the living body. Although OI technologies are still limited by light scattering and depth of light penetration they provide a low cost and rapid alternative to the more expensive and time‐consuming PET imaging. By introducing multi‐modality reporter constructs (PET, fluorescence and/or bioluminescence) drawbacks of each modality can be overcome and advantages will complement one another. Thus, allowing on the one side rapid, cost‐effective optical reporter imaging and on the other side tomographic as well as quantitative imaging of reporter gene expression by PET. With PET being a modality well developed for imaging in human subjects as well as small animals it provides a link from bench‐to‐bedside and may facilitate translation into clinical applications. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):CN01-04." @default.
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- W2275984853 date "2009-12-10" @default.
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- W2275984853 title "Abstract CN01-04: Imaging‐guided therapy in different tumor models using positron emission tomography (PET) and optical imaging" @default.
- W2275984853 doi "https://doi.org/10.1158/1535-7163.targ-09-cn01-04" @default.
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