FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275989970> ?p ?o ?g. }

• W2275989970 endingPage "2170" @default.
• W2275989970 startingPage "2159" @default.
• W2275989970 abstract "Membrane transporters (such as ABCs, SLCs and ATPases) act in carcinogenesis and chemoresistance development, but their relevance for prognosis of epithelial ovarian cancer (EOC) remains poorly understood. We evaluated the gene expression profile of 39 ABC and 12 SLC transporters and three ATPases in EOC tissues and addressed their putative role in prognosis and clinical course of EOC patients. Relative gene expression in a set of primary EOC (n=57) and in control ovarian tissues (n=14) was estimated and compared with clinical data and survival of patients. Obtained data were validated in an independent set of patients (n=60). Six ABCs and SLC22A18 gene were significantly overexpressed in carcinomas when compared with controls, while expression of 12 ABCs, five SLCs, ATP7A and ATP11B was decreased. Expression of ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 was higher in high grade serous carcinoma compared with other subtypes. ABCA2 gene expression significantly associated with EOC grade in both sets of patients. Notably, expression level of ABCA9, ABCA10, ABCC9 and SLC16A14 significantly associated with progression-free survival (PFS) of the disease in either pilot or validation sets. ABCG2 level associated with PFS in the pooled set of patients. In conclusion, ABCA2, ABCA9, ABCA10, ABCC9, ABCG2 and SLC16A14 present novel putative markers of EOC progression and together with the revealed relationship between ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 expression, and high grade serous type of EOC should be further examined by larger follow-up study." @default.
• W2275989970 created "2016-06-24" @default.
• W2275989970 creator A5004651940 @default.
• W2275989970 creator A5020483926 @default.
• W2275989970 creator A5021244258 @default.
• W2275989970 creator A5024764561 @default.
• W2275989970 creator A5032349747 @default.
• W2275989970 creator A5034078040 @default.
• W2275989970 creator A5036829595 @default.
• W2275989970 creator A5041810909 @default.
• W2275989970 creator A5047830770 @default.
• W2275989970 creator A5065943539 @default.
• W2275989970 creator A5068588225 @default.
• W2275989970 creator A5077917038 @default.
• W2275989970 creator A5090756163 @default.
• W2275989970 date "2016-01-28" @default.
• W2275989970 modified "2023-10-18" @default.
• W2275989970 title "Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma" @default.
• W2275989970 cites W1493801922 @default.
• W2275989970 cites W1550210631 @default.
• W2275989970 cites W1832759482 @default.
• W2275989970 cites W1970083157 @default.
• W2275989970 cites W1980184671 @default.
• W2275989970 cites W1981045629 @default.
• W2275989970 cites W1981989535 @default.
• W2275989970 cites W1990692334 @default.
• W2275989970 cites W1992882573 @default.
• W2275989970 cites W2000130246 @default.
• W2275989970 cites W2015030879 @default.
• W2275989970 cites W2028509307 @default.
• W2275989970 cites W2031576290 @default.
• W2275989970 cites W2032879513 @default.
• W2275989970 cites W2052715533 @default.
• W2275989970 cites W2055067929 @default.
• W2275989970 cites W2056643204 @default.
• W2275989970 cites W2057238668 @default.
• W2275989970 cites W2063305734 @default.
• W2275989970 cites W2070257831 @default.
• W2275989970 cites W2071187512 @default.
• W2275989970 cites W2074920127 @default.
• W2275989970 cites W2090968329 @default.
• W2275989970 cites W2096204304 @default.
• W2275989970 cites W2098885754 @default.
• W2275989970 cites W2113689159 @default.
• W2275989970 cites W2135254067 @default.
• W2275989970 cites W2163691988 @default.
• W2275989970 cites W2166078169 @default.
• W2275989970 cites W2168420558 @default.
• W2275989970 cites W2316860190 @default.
• W2275989970 cites W2407433978 @default.
• W2275989970 cites W4231400033 @default.
• W2275989970 cites W4249697459 @default.
• W2275989970 doi "https://doi.org/10.3892/or.2016.4599" @default.
• W2275989970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26820484" @default.
• W2275989970 hasPublicationYear "2016" @default.
• W2275989970 type Work @default.
• W2275989970 sameAs 2275989970 @default.
• W2275989970 citedByCount "50" @default.
• W2275989970 countsByYear W22759899702016 @default.
• W2275989970 countsByYear W22759899702017 @default.
• W2275989970 countsByYear W22759899702018 @default.
• W2275989970 countsByYear W22759899702019 @default.
• W2275989970 countsByYear W22759899702020 @default.
• W2275989970 countsByYear W22759899702021 @default.
• W2275989970 countsByYear W22759899702022 @default.
• W2275989970 countsByYear W22759899702023 @default.
• W2275989970 crossrefType "journal-article" @default.
• W2275989970 hasAuthorship W2275989970A5004651940 @default.
• W2275989970 hasAuthorship W2275989970A5020483926 @default.
• W2275989970 hasAuthorship W2275989970A5021244258 @default.
• W2275989970 hasAuthorship W2275989970A5024764561 @default.
• W2275989970 hasAuthorship W2275989970A5032349747 @default.
• W2275989970 hasAuthorship W2275989970A5034078040 @default.
• W2275989970 hasAuthorship W2275989970A5036829595 @default.
• W2275989970 hasAuthorship W2275989970A5041810909 @default.
• W2275989970 hasAuthorship W2275989970A5047830770 @default.
• W2275989970 hasAuthorship W2275989970A5065943539 @default.
• W2275989970 hasAuthorship W2275989970A5068588225 @default.
• W2275989970 hasAuthorship W2275989970A5077917038 @default.
• W2275989970 hasAuthorship W2275989970A5090756163 @default.
• W2275989970 hasBestOaLocation W22759899701 @default.
• W2275989970 hasConcept C121608353 @default.
• W2275989970 hasConcept C126322002 @default.
• W2275989970 hasConcept C142724271 @default.
• W2275989970 hasConcept C143998085 @default.
• W2275989970 hasConcept C150173356 @default.
• W2275989970 hasConcept C2780427987 @default.
• W2275989970 hasConcept C2781018059 @default.
• W2275989970 hasConcept C29537977 @default.
• W2275989970 hasConcept C3019054536 @default.
• W2275989970 hasConcept C502942594 @default.
• W2275989970 hasConcept C555283112 @default.
• W2275989970 hasConcept C71924100 @default.
• W2275989970 hasConcept C86803240 @default.
• W2275989970 hasConceptScore W2275989970C121608353 @default.
• W2275989970 hasConceptScore W2275989970C126322002 @default.
• W2275989970 hasConceptScore W2275989970C142724271 @default.
• W2275989970 hasConceptScore W2275989970C143998085 @default.

• next