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- W2275991589 abstract "The glucuronic acid conjugate of Chloromycetin is absorbed more rapidly from subcutaneous sites of injection than Chloromycetin, but when given orally the rate of absorption is less than that observed with Chloromycetin. In the caecum and large intestine of the rat the glucuronide is readily hydrolyzed by bacterial action, and large quantities of aromatic amines are formed by reduction of the nitro group. The Chloromycetin and the amines resulting from the degradation of the glucuronide in the lower intestinal tract are partly absorbed, and eventually appear in the urine. Some of the metabolic products of Chloromycetin in rat urine are characterized by paper chromatography." @default.
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- W2275991589 date "1952-04-01" @default.
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- W2275991589 title "Observations on the metabolic disposition of chloramphenicol (chloromycetin) in the rat." @default.
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