FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2275997631> ?p ?o ?g. }

• W2275997631 abstract "Significance T-cell receptor (TCR) recognition of antigenic peptides presented by major histocompatibility complex (MHC) proteins defines specificity in cellular immunity. Evidence suggests that TCRs are intrinsically biased toward MHC proteins, yet how this bias coexists alongside the considerable structural variability that is necessary for TCRs to engage different ligands has been a longstanding puzzle. By examining structural and sequence data, we found evidence that human αβ TCRs have an inherent compatibility with structural and chemical properties of MHC proteins. This compatibility leads TCRs to an intrinsic MHC bias but does not compel the formation of particular modes of binding, providing a solution to how TCRs can be MHC-biased but still structurally adaptable." @default.
• W2275997631 created "2016-06-24" @default.
• W2275997631 creator A5017774638 @default.
• W2275997631 creator A5031631712 @default.
• W2275997631 creator A5034268558 @default.
• W2275997631 creator A5046287489 @default.
• W2275997631 creator A5054867553 @default.
• W2275997631 creator A5082462618 @default.
• W2275997631 creator A5084369008 @default.
• W2275997631 creator A5088896967 @default.
• W2275997631 creator A5089406789 @default.
• W2275997631 date "2016-02-16" @default.
• W2275997631 modified "2023-10-01" @default.
• W2275997631 title "How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire" @default.
• W2275997631 cites W1481861927 @default.
• W2275997631 cites W1497032543 @default.
• W2275997631 cites W1548757996 @default.
• W2275997631 cites W1674556171 @default.
• W2275997631 cites W1830045534 @default.
• W2275997631 cites W1865427247 @default.
• W2275997631 cites W1868344454 @default.
• W2275997631 cites W1919861825 @default.
• W2275997631 cites W1957303876 @default.
• W2275997631 cites W1967965427 @default.
• W2275997631 cites W1973836350 @default.
• W2275997631 cites W1975653912 @default.
• W2275997631 cites W1978069717 @default.
• W2275997631 cites W1978090240 @default.
• W2275997631 cites W1980048816 @default.
• W2275997631 cites W1980215591 @default.
• W2275997631 cites W1980959963 @default.
• W2275997631 cites W1983660668 @default.
• W2275997631 cites W1987993651 @default.
• W2275997631 cites W1989031639 @default.
• W2275997631 cites W1992208719 @default.
• W2275997631 cites W1993585699 @default.
• W2275997631 cites W1998240361 @default.
• W2275997631 cites W2006732227 @default.
• W2275997631 cites W2011639909 @default.
• W2275997631 cites W2020739249 @default.
• W2275997631 cites W2021310372 @default.
• W2275997631 cites W2021534482 @default.
• W2275997631 cites W2023323249 @default.
• W2275997631 cites W2024875935 @default.
• W2275997631 cites W2026488678 @default.
• W2275997631 cites W2032428654 @default.
• W2275997631 cites W2035866208 @default.
• W2275997631 cites W2038509173 @default.
• W2275997631 cites W2042594873 @default.
• W2275997631 cites W2042964520 @default.
• W2275997631 cites W2043080692 @default.
• W2275997631 cites W2046763527 @default.
• W2275997631 cites W2048608556 @default.
• W2275997631 cites W2051152071 @default.
• W2275997631 cites W2053472272 @default.
• W2275997631 cites W2056034415 @default.
• W2275997631 cites W2063184115 @default.
• W2275997631 cites W2067979613 @default.
• W2275997631 cites W2070711733 @default.
• W2275997631 cites W2072541925 @default.
• W2275997631 cites W2073392655 @default.
• W2275997631 cites W2075216746 @default.
• W2275997631 cites W2075799289 @default.
• W2275997631 cites W2077864494 @default.
• W2275997631 cites W2079683161 @default.
• W2275997631 cites W2079759605 @default.
• W2275997631 cites W2081090613 @default.
• W2275997631 cites W2083901781 @default.
• W2275997631 cites W2084653587 @default.
• W2275997631 cites W2088407586 @default.
• W2275997631 cites W2096803586 @default.
• W2275997631 cites W2097602001 @default.
• W2275997631 cites W2098103958 @default.
• W2275997631 cites W2101553545 @default.
• W2275997631 cites W2106320506 @default.
• W2275997631 cites W2109086160 @default.
• W2275997631 cites W2113488569 @default.
• W2275997631 cites W2113773464 @default.
• W2275997631 cites W2116117984 @default.
• W2275997631 cites W2123930600 @default.
• W2275997631 cites W2132226411 @default.
• W2275997631 cites W2132826139 @default.
• W2275997631 cites W2134724359 @default.
• W2275997631 cites W2139445045 @default.
• W2275997631 cites W2140279834 @default.
• W2275997631 cites W2140950597 @default.
• W2275997631 cites W2142336102 @default.
• W2275997631 cites W2142843496 @default.
• W2275997631 cites W2146040535 @default.
• W2275997631 cites W2146074801 @default.
• W2275997631 cites W2146652028 @default.
• W2275997631 cites W2148323928 @default.
• W2275997631 cites W2151271464 @default.
• W2275997631 cites W2155740919 @default.
• W2275997631 cites W2158266834 @default.
• W2275997631 cites W2170820778 @default.
• W2275997631 cites W2268663278 @default.
• W2275997631 cites W4239551491 @default.
• W2275997631 doi "https://doi.org/10.1073/pnas.1522069113" @default.
• W2275997631 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4780628" @default.

• next