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- W2276019318 abstract "Type IV collagen (IV-C) is one of the main component of basement membrane. The purpose of this study was to assess the clinical significance of assay serum IV-7S (7S collagen) in patients with hepatitis B related liver disease. Compared with a prognostic value of the Child-Pugh's score, and the Galactose elimination capacity (GEC) test.Serum collagen IV-75 (7S collagen) was measured in 176 patients with hepatitis B-related liver disease and 20 healthy controls. 7S collagen was determined with a radioimmunoassay kit purchased from Nippon DPC corporation (Tokyo, Japan). Galactose elimination capacity (GEC) was calculated according to Tysgstrup's equation.The serum concentrations of 7S collagen (mean ±SD) were 3.41 ± 0.62 ng/ml in controls, 6.23 ± 3.47 ng/ml in acute hepatitis (AH), 7.1 ± 5.34 ng/ml in chronic hepatitis (CH) and 14.71 ± 8.l9ng/ml in liver cirrhosis (LC). In CH, 7S collagen concentration was slightly increased than that in the control. In LC, 7S collagen concentration was markedly increased than that in the control, AH and CH. 7S Collagen did not correlate with serum ALT levels in AH and CH but there have been relationships between serum ALT levels and 7S collagen concentration in patients with LC. In patients with LC, the serum concentrations of 7S collagen was significantly correlated with the serum levels of albumin and compared with a Child-Pugh score (pcO.01), but Galactose elimination capacity (GEC) values had a more significant relationship compared with the Child-Pugh score (p<0.001).These data suggested that the serum concentration of 7S collagen could be useful for evaluation of the disease process of hepatitis B-related liver disease but the prognostic value of the GEC was by far superior to the serum concentration of 7S collagen." @default.
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- W2276019318 date "1998-04-01" @default.
- W2276019318 modified "2023-10-18" @default.
- W2276019318 title "The Clinical Significance of Assay Serum Collagen IV 7S Collagen in Patients with Hepatitis B-Related Liver Disease" @default.
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