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- W2276287788 endingPage "179" @default.
- W2276287788 startingPage "159" @default.
- W2276287788 abstract "Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal loss in acute and chronic neurological conditions such as ischaemic stroke, Alzheimer's and Huntington's diseases. Effective neuroprotective drugs to reduce excitotoxic neuronal loss in patients suffering from these neurological conditions are urgently needed. One avenue to achieve this goal is to clearly define the intracellular events mediating the neurotoxic signals originating from the over-stimulated glutamate receptors in neurons. In this review, we first focus on the key cellular events directing neuronal death but not involved in normal physiological processes in the neurotoxic signalling pathways. These events, referred to as pathologically activated events, are potential targets for the development of neuroprotectant therapeutics. Inhibitors blocking some of the known pathologically activated cellular events have been proven to be effective in reducing stroke-induced brain damage in animal models. Notable examples are inhibitors suppressing the ion channel activity of neurotoxic glutamate receptors and those disrupting interactions of specific cellular proteins occurring only in neurons undergoing excitotoxic cell death. Among them, Tat-NR2B9c and memantine are clinically effective in reducing brain damage caused by some acute and chronic neurological conditions. Our second focus is evaluation of the suitability of the other inhibitors for use as neuroprotective therapeutics. We also discuss the experimental approaches suitable for bridging our knowledge gap in our current understanding of the excitotoxic signalling mechanism in neurons and discovery of new pathologically activated cellular events as potential targets for neuroprotection." @default.
- W2276287788 created "2016-06-24" @default.
- W2276287788 creator A5010616192 @default.
- W2276287788 creator A5017246405 @default.
- W2276287788 creator A5023474167 @default.
- W2276287788 creator A5031778162 @default.
- W2276287788 creator A5038232997 @default.
- W2276287788 creator A5041099966 @default.
- W2276287788 creator A5053613738 @default.
- W2276287788 creator A5057747777 @default.
- W2276287788 creator A5089222354 @default.
- W2276287788 date "2016-04-01" @default.
- W2276287788 modified "2023-09-27" @default.
- W2276287788 title "A beacon of hope in stroke therapy—Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies" @default.
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