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• W2276346095 abstract "40 Identification of Potential Drug Resistant Mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART H Wu, HJ Zhang, XM Zhang, QW Zhang, and BJ Zheng Department of Microbiology, the University of Hong Kong, Hong Kong BACKGROUND: This study aimed to identify potential drug resistant mutations in proviral DNA in HIV patients with long-term undetectable viral load after receiving HAART . METHOD: Peripheral blood mononuclear cells (PBMC) were collected from 45 patients twice per year from 2005 to 2009 . These patients have been receiving effective highly active antiretroviral therapy (HAART) for 3 to 13 years . The env gene (C2V5), protease (PR) gene and the first 400 codons of the reverse transcriptase (RT) gene were amplified from PBMC DNA, sequenced and subjected to phylogenetic analysis . RESUTS: A total of 190 sequences of PR and RT and 37 sequences of C2V5 region of env gene were amplified from PBMC samples of the patients . C2V5 amplification failed in 8 patients, while PR and RT amplification failed in 7 patients . According to sequencing results of C2V5 or PR and RT genes, 29 (70 .7%) patients were infected by HIV-1 AE subtype, 8 (19 .6%), 3 (7 .3%) and 1(2 .4%) patients were infected by B and C and CRF08_ BC subtypes, respectively . Thymidine analog mutation (TAM) type II pattern selected by the thymidine analogs was detected in 5 patients who have received antiretroviral therapy for about 10 years . Two of these 5 patients also developed multi-nucleoside resistance mutation Q151M and M184I, respectively . The most common NRTI resistance mutation, M184V, was found in two patients, including one who developed major protease inhibitor resistance mutation L90M . No any drug-resistant mutation was found in the other 14 patients who have received CBV-based or 3TC/ ABC based treatment for 3 to 12 years . Phylogenetic analysis showed short genetic distances in different time points during treatment . CONCLUSIONS: TAM type II pattern mutations can persist in provial DNA for longer than 10 years . The possibility of developing major resistant mutations is low and proviral DNA evolution is limited in patients with successful HAART ." @default.
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• W2276346095 date "2010-01-01" @default.
• W2276346095 modified "2023-09-27" @default.
• W2276346095 title "Identification of potential drug resistant mutations in HIV-1 infected patients with long-term undetectable viral load after receiving HAART" @default.
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