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- W2276382016 abstract "Abstract Background Human papillomavirus (HPV) has been implicated as playing a causal role in Barrett’s esophagus, the metaplastic precursor to esophageal adenocarcinomas (EAC) and gastro-esophageal junction adenocarcinomas (GEJACs). We evaluated the presence of HPV DNA in EACs and GEJACs. Study design We analyzed 241 histologically confirmed archived EAC and GEJAC tissue specimens from a population-based study in Australia. Samples were tested by PCR for DNA quality (β-globin) and for the presence of HPV DNA. Results DNA yield and quality was satisfactory in 97% (233/241; 201 EAC, 32 GEJAC). Each sample was tested three times for HPV DNA, but none of the 233 tumor specimens tested positive. Conclusions We found no evidence of HPV DNA in esophageal adenocarcinoma tumor cells. HPV is unlikely to cause EAC or GEJAC." @default.
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- W2276382016 date "2016-08-01" @default.
- W2276382016 modified "2023-09-29" @default.
- W2276382016 title "Human papillomavirus not detected in esophageal adenocarcinoma tumor specimens-Reply" @default.
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- W2276382016 doi "https://doi.org/10.1016/j.canep.2016.05.005" @default.
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