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• W2276460438 abstract "Memory dysfunction in mild cognitive impairment (MCI) is primarily associated with episodic memory deficits linked to deterioration of the medial temporal lobes (MTLs). Current suggested criteria for the diagnosis of MCI call for the discovery of novel biomarkers. Functional activation differences in MCI during memory-task performance are often evidenced in the MTLs, and frontal and parietal lobes, but it has been suggested that examination of working memory (WKM) differences may be more useful in detecting MCI. In the current study, MCI and control participants performed a complex WKM span (CWKMS) task while functional magnetic resonance imaging (fMRI) data was acquired. Results indicated hyper-activation of the superior temporal gyrus (STG), MTLs, and the insula during encoding and maintenance, and hyperactivation of the STG, MTLs, insula, and ventromedial frontal and anterior cingulated cortices during recall for the MCI participants. MTL differences are consistent with previous findings, but such localized differences in the STG are quite novel. Hyper- activation of the STG during WKM encoding and maintenance suggests that long-term phonological mechanisms associated with regions of the STG are necessary to maintain items in the focus attention. Increased recruitment of these mechanisms for the MCI patients suggests that may be attempting to compensate for poor encoding abilities that may partly resulted from MTL neurodegeneration. Therefore, hyper-activation of the STG during WKM encoding and maintenance, and/or recall is a possible novel biomarker" @default.
• W2276460438 created "2016-06-24" @default.
• W2276460438 creator A5073298039 @default.
• W2276460438 date "2012-12-01" @default.
• W2276460438 modified "2023-09-27" @default.
• W2276460438 title "Functional and diffusion MRI biomarkers of mild cognitive impairment" @default.
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