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- W2276485983 abstract "Intravesical resiniferatoxin has been used to treat both neuropathic detrusor overactivity and idiopathic detrusor overactivity. We aimed to administer resiniferatoxin to a large cohort of patients with idiopathic detrusor overactivity, refractory to treatment with >2 antimuscarinic drugs for >12 months, and to characterise success in relation to predefined clinical subgroups. Females aged 25-90 years, with urodynamically proven refractory idiopathic detrusor overactivity (median duration 14 years) were administered resiniferatoxin (100 ml at 50 nM). Outcome measures (voids per day, nocturia, urgency episodes per day, leaks per day), the ICIQ, and quality of life tests (UDI, OABQ, IIQ), were performed at baseline, one and three months. Analysis (n=33) showed that resiniferatoxin conferred significant (p<0.05) benefit on leaks per day (from four (IQR 3-6) to three (IQR 1-5)), ICIQ and OABQ. Eleven patients were found to have an episode of bacterial cystitis without dysuria, at some stage during the study, and resiniferatoxin was without benefit in such women. When those with cystitis were excluded, resiniferatoxin showed heightened improvement in leaks per day (p=0.009), ICIQ (p=0.016), OABQ (p=0.002) and IIQ (p=0.003). Analysis of four clinical subgroups: congenital (for example, childhood daywetting); post-bladder neck surgery; history of recurrent cystitis; and completely idiopathic, showed no clear effect of resiniferatoxin. Resiniferatoxin showed a modest improvement in leaks per day and quality of life symptoms in women with severe refractory idiopathic detrusor overactivity, who had no episodes of bacterial cystitis. In contrast, resiniferatoxin was ineffective in women with any cystitis during the trial. Because cystitis episodes were asymptomatic, detailed microbiological scrutiny of urine from women with refractory idiopathic detrusor overactivity appears warranted in future." @default.
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- W2276485983 date "2013-01-01" @default.
- W2276485983 modified "2023-10-03" @default.
- W2276485983 title "Response to resiniferatoxin in women with refractory detrusor overactivity: Role of bacterial cystitis" @default.
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