Matches in SemOpenAlex for { <https://semopenalex.org/work/W2276492661> ?p ?o ?g. }
- W2276492661 endingPage "1173" @default.
- W2276492661 startingPage "1163" @default.
- W2276492661 abstract "Radioresistance remains a major problem in the treatment of patients suffering from nasopharyngeal carcinoma (NPC). A better understanding of the mechanisms of radioresistance may generate new strategies to improve NPC patients' responses to therapy. This study was designed to investigate the effect of microRNA on the radiosensitivity of NPC cells. A microRNA microarray indicated that miR-24 was downregulated in NPC cell lines and tissues. Furthermore, cell proliferation was suppressed and radiosensitivity increased when miR-24 was ectopically expressed in NPC cells. Specificity protein 1 (SP1) was additionally verified as a direct functional target of miR-24, which was found to be involved in cell viability as well as the radiosensitivity of NPC cells. In conclusion, the results of this study suggest that the miR-24/SP1 pathway contributed to the reduction in radioresistance in human NPC and that it may thus represent a therapeutic target." @default.
- W2276492661 created "2016-06-24" @default.
- W2276492661 creator A5037631027 @default.
- W2276492661 creator A5042174545 @default.
- W2276492661 creator A5043827727 @default.
- W2276492661 creator A5059574998 @default.
- W2276492661 creator A5059798382 @default.
- W2276492661 creator A5083589773 @default.
- W2276492661 creator A5088449134 @default.
- W2276492661 date "2016-02-29" @default.
- W2276492661 modified "2023-10-18" @default.
- W2276492661 title "MiR‐24 enhances radiosensitivity in nasopharyngeal carcinoma by targeting <scp>SP</scp> 1" @default.
- W2276492661 cites W1502936039 @default.
- W2276492661 cites W1527599612 @default.
- W2276492661 cites W1538151223 @default.
- W2276492661 cites W1978055937 @default.
- W2276492661 cites W1997261348 @default.
- W2276492661 cites W2002995168 @default.
- W2276492661 cites W2003600574 @default.
- W2276492661 cites W2003631713 @default.
- W2276492661 cites W2009638448 @default.
- W2276492661 cites W2011904430 @default.
- W2276492661 cites W2012484706 @default.
- W2276492661 cites W2028418967 @default.
- W2276492661 cites W2039213901 @default.
- W2276492661 cites W2042568017 @default.
- W2276492661 cites W2049069126 @default.
- W2276492661 cites W2052448530 @default.
- W2276492661 cites W2052788204 @default.
- W2276492661 cites W2054054984 @default.
- W2276492661 cites W2056230262 @default.
- W2276492661 cites W2066027374 @default.
- W2276492661 cites W2079614925 @default.
- W2276492661 cites W2081735304 @default.
- W2276492661 cites W2098323664 @default.
- W2276492661 cites W2112059983 @default.
- W2276492661 cites W2116632332 @default.
- W2276492661 cites W2117391818 @default.
- W2276492661 cites W2125536613 @default.
- W2276492661 cites W2131482305 @default.
- W2276492661 cites W2135314242 @default.
- W2276492661 cites W2135613885 @default.
- W2276492661 cites W2136542410 @default.
- W2276492661 cites W2146278947 @default.
- W2276492661 cites W2147748396 @default.
- W2276492661 cites W2160918828 @default.
- W2276492661 cites W2161320250 @default.
- W2276492661 cites W2161739409 @default.
- W2276492661 cites W2162674813 @default.
- W2276492661 cites W2167142486 @default.
- W2276492661 cites W2170514882 @default.
- W2276492661 cites W2171461504 @default.
- W2276492661 cites W4211070369 @default.
- W2276492661 doi "https://doi.org/10.1002/cam4.660" @default.
- W2276492661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4924375" @default.
- W2276492661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26922862" @default.
- W2276492661 hasPublicationYear "2016" @default.
- W2276492661 type Work @default.
- W2276492661 sameAs 2276492661 @default.
- W2276492661 citedByCount "36" @default.
- W2276492661 countsByYear W22764926612015 @default.
- W2276492661 countsByYear W22764926612016 @default.
- W2276492661 countsByYear W22764926612017 @default.
- W2276492661 countsByYear W22764926612018 @default.
- W2276492661 countsByYear W22764926612019 @default.
- W2276492661 countsByYear W22764926612020 @default.
- W2276492661 countsByYear W22764926612021 @default.
- W2276492661 countsByYear W22764926612022 @default.
- W2276492661 countsByYear W22764926612023 @default.
- W2276492661 crossrefType "journal-article" @default.
- W2276492661 hasAuthorship W2276492661A5037631027 @default.
- W2276492661 hasAuthorship W2276492661A5042174545 @default.
- W2276492661 hasAuthorship W2276492661A5043827727 @default.
- W2276492661 hasAuthorship W2276492661A5059574998 @default.
- W2276492661 hasAuthorship W2276492661A5059798382 @default.
- W2276492661 hasAuthorship W2276492661A5083589773 @default.
- W2276492661 hasAuthorship W2276492661A5088449134 @default.
- W2276492661 hasBestOaLocation W22764926611 @default.
- W2276492661 hasConcept C104317684 @default.
- W2276492661 hasConcept C126322002 @default.
- W2276492661 hasConcept C145059251 @default.
- W2276492661 hasConcept C1491633281 @default.
- W2276492661 hasConcept C206684579 @default.
- W2276492661 hasConcept C2778997737 @default.
- W2276492661 hasConcept C502942594 @default.
- W2276492661 hasConcept C509974204 @default.
- W2276492661 hasConcept C54355233 @default.
- W2276492661 hasConcept C58962609 @default.
- W2276492661 hasConcept C62112901 @default.
- W2276492661 hasConcept C71924100 @default.
- W2276492661 hasConcept C81885089 @default.
- W2276492661 hasConcept C86803240 @default.
- W2276492661 hasConceptScore W2276492661C104317684 @default.
- W2276492661 hasConceptScore W2276492661C126322002 @default.
- W2276492661 hasConceptScore W2276492661C145059251 @default.
- W2276492661 hasConceptScore W2276492661C1491633281 @default.
- W2276492661 hasConceptScore W2276492661C206684579 @default.
- W2276492661 hasConceptScore W2276492661C2778997737 @default.