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- W2276571859 abstract "In normal adults, the majority of primitive hematopoietic cells are concentrated in the bone marrow, where they are in contact with a variety of molecules that influence their cell-cycle status, viability, motility, and differentiation. These include components of the extracellular matrix, soluble and bound growth-promoting factors and inhibitors, and adhesion molecules that mediate direct interactions between cells. The long-term culture (LTC) system initially developed to support the continued production of myeloid cells, (, , ) and subsequently for the production of lymphoid cells (, , , ) has provided a unique approach for the investigation of the regulation and maintenance of early hematopoietic progenitors under conditions that reproduce many aspects of the marrow microenvironment. The LTC system has also provided a basis for the development of powerful assay procedures for quantitating and distinguishing cells at discrete stages of early hematopoietic cell differentiation." @default.
- W2276571859 created "2016-06-24" @default.
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- W2276571859 date "2003-11-14" @default.
- W2276571859 modified "2023-10-06" @default.
- W2276571859 title "Long-Term Culture-Initiating Cell Assays for Human and Murine Cells" @default.
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- W2276571859 doi "https://doi.org/10.1385/1-59259-140-x:123" @default.
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