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- W2276751188 endingPage "1163" @default.
- W2276751188 startingPage "1144" @default.
- W2276751188 abstract "Members of the matrix metalloproteinase (MMP) family have been identified as poor prognosis markers for breast cancer patients and as drivers of many facets of the tumor phenotype in experimental models. Early enthusiasm for MMPs as therapeutic targets was tempered following disappointing clinical trials that utilized broad spectrum, small molecule catalytic site inhibitors. However, subsequent research has continued to define key roles for MMPs as breast cancer promoters, to elucidate the complex roles that that these proteins play in breast cancer development and progression, and to identify how these roles are linked to specific and unique biochemical features of individual members of the MMP family. Here, we provide an overview of the structural features of the MMPs, then discuss clinical studies identifying which MMP family members are linked with breast cancer development and new experimental studies that reveal how these specific MMPs may play unique roles in the breast cancer microenvironment. We conclude with a discussion of the most promising avenues for development of therapeutic agents capable of targeting the tumor-promoting properties of MMPs." @default.
- W2276751188 created "2016-06-24" @default.
- W2276751188 creator A5048587108 @default.
- W2276751188 creator A5084693147 @default.
- W2276751188 date "2015-01-01" @default.
- W2276751188 modified "2023-10-16" @default.
- W2276751188 title "Matrix metalloproteinases as drivers and therapeutic targets in breast cancer" @default.
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