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- W2276760947 abstract "Background: NH125, a known WalK inhibitor kills MRSA persisters. However, its precise mode of action is still unknown. Methods & results: The mode of action of NH125 was investigated by comparing its spectrum of antimicrobial activity and its effects on membrane permeability and giant unilamellar vesicles (GUVs) with walrycin B, a WalR inhibitor and benzyldimethylhexadecylammonium chloride (16-BAC), a cationic surfactant. NH125 killed persister cells of a variety of Staphylococcus aureus strains. Similar to 16-BAC, NH125 killed MRSA persisters by inducing rapid membrane permeabilization and caused the rupture of GUVs, whereas walrycin B did not kill MRSA persisters or induce membrane permeabilization and did not affect GUVs. Conclusion: NH125 kills MRSA persisters by interacting with and disrupting membranes in a detergent-like manner." @default.
- W2276760947 created "2016-06-24" @default.
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- W2276760947 date "2016-03-01" @default.
- W2276760947 modified "2023-09-27" @default.
- W2276760947 title "NH125 kills methicillin-resistant <i>Staphylococcus aureus</i> persisters by lipid bilayer disruption" @default.
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- W2276760947 doi "https://doi.org/10.4155/fmc.15.189" @default.
- W2276760947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4976882" @default.
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- W2276760947 hasPublicationYear "2016" @default.
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