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- W2276770157 abstract "Phase I and II clinical trials have demonstrated acceptable toxicity and promising activity of Edatrexate (10-EDAM). The objective of this multicentre phase II study was to determine the efficacy and toxicity of this agent in patients with metastatic melanoma.Sixteen previously untreated patients with metastatic melanoma received 10-EDAM, 80 mg/m2/week intravenously. Patients were evaluated for response and toxicity.There were no objective responses. The median dose intensity of 10-EDAM actually delivered was 56.25 mg/m2/week (70% of projected). Mucositis of any degree was encountered in 93.8% of patients. Grade 3 or 4 mucositis, skin rash, nausea, abdominal pain, neutropenia, thrombocytopenia, anemia and hyperbilirubinemia each were encountered in 1-2 patients. There was 1 toxic death due to 10-EDAM.10-EDAM is an inactive agent in metastatic melanoma." @default.
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- W2276770157 date "1993-03-01" @default.
- W2276770157 modified "2023-10-18" @default.
- W2276770157 title "A phase II study of weekly Edatrexate (10-EDAM) in metastatic melanoma" @default.
- W2276770157 cites W1985025279 @default.
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- W2276770157 doi "https://doi.org/10.1093/oxfordjournals.annonc.a058467" @default.
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