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- W2276841944 abstract "2386 Objectives We investigate the design of a very high spatial resolution PET detector with time-of-flight (TOF) and depth of interaction (DOI) positioning capability. The detector is designed as an insert device to improve spatial resolution for limited volume imaging within a PET system’s field of view. The optimization of TOF performance is critical as TOF improves image quality for the limited angle PET imaging geometry. Methods Two detector designs were investigated. They each consisted of a 25.6 by 25.6 by 12.8 mm^3 monolithic LYSO crystal readout by arrays of silicon photomultiplier (SiPM) devices. For one design SiPM arrays were coupled to all six sides of the detector. For the second design SiPM arrays were only coupled to the two 25.6 by 25.6 mm^2 surfaces. Simulation studies using DETECT and GEANT were used to investigate the intrinsic spatial resolution of the detectors. 2D and 3D calibration procedures were used for the two-sided and six-sided readout designs, respectively. Simulation studies using SCOUT were used to investigate the arrival times of the first through tenth detected light photons. Effects of DOI resolution were included in the simulation of photon arrival times. The FWHM of the arrival times combined with the intrinsic timing capabilities of a SiPM device establishes the intrinsic timing capability of a detector. Results Performance results are listed in Table 1. The main advantage of the six-sided readout was improved positioning along the edge of the detector and significantly better DOI spatial resolution. The average FWHMs of the arrival times of the 4th detected light photon for two different regions of the detector are listed in Table 1. Depending upon the photon origination point, the six-sided detector had 31-38% better timing performance. Conclusions An ultra high performance, TOF, DOI PET insert detector can be designed using a monolithic crystal detector readout by SiPM arrays. Six-sided readout with fully 3D calibration provides optimum performance. Research Support NIH grants NCI CA136569, NIBIB EB001563 and EB200117 and DOE DE-FG02-05ER1570" @default.
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- W2276841944 date "2012-05-01" @default.
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- W2276841944 title "Simulation study of a time-of-flight, depth of interaction PET insert detector" @default.
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