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- W2276894395 abstract "e14087 Background: LI-cadherin is a member of the group of 7D-cadherins. In humans, LI-cadherin is physiologically expressed in the basolateral cell membrane of the epithelia of the small and large intestine. However, expression has also been reported for colonic, gastric, pancreatic and hepatic adenocarcinomas as well as for intestinal metaplasia of the stomach. In this study we analyzed the expression of LI-cadherin in hepatic and pulmonary metastases of colorectal carcinomas and compared the expression to primary malignancies of these organs. Methods: We analyzed the expression of LI-cadherin in 77 primary malignant liver neoplasias (21 hepatocellular carcinomas, 56 cholangiocarcinomas), 28 colorectal liver metastases, 53 primary malignant lung carcinomas and 18 colorectal lung metastases. A polyclonal antibody raised against the cytoplasmatic domain of LI- cadherin was used to immunhistochemically stain paraffin embedded thin sections as well as tissue microarrays. Results: All colorectal liver metastases and 83 % of colorectal lung metastases showed strong, membrane specific staining for LI-cadherin. In contrast, none of the hepatocellular carcinomas and only 4 % of lung cancers were positive for LI-cadherin. In cholangiocarcinomas we observed positive staining in 27% of cases. Conclusions: LI-cadherin is strongly expressed at an early stage of malignant transformation and remains upregulated in distant metastases of colorectal carcinomas. Compared to that, E-cadherin is often downregulated in malignant tumors and in metastases. LI-cadherin expression could solely be observed in adenocarcinomas of entodermal origin and it may specifically serve as a histopathological differentiation marker for distant colorectal metastases. No significant financial relationships to disclose." @default.
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- W2276894395 date "2010-05-20" @default.
- W2276894395 modified "2023-09-25" @default.
- W2276894395 title "LI-cadherin expression in distant metastases of colorectal carcinoma: A potential differentiation marker." @default.
- W2276894395 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.e14087" @default.
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