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• W2277038540 abstract "Here we provide a standardized protocol for performing distal middle cerebral artery occlusion (DMCAO) in mice. DMCAO is a method of inducing permanent focal ischemia that is commonly used as a rodent stroke model. To perform DMCAO a temporal craniotomy is performed, and the middle cerebral artery (MCA) is permanently ligated at a point downstream of the lenticulostriate branches. The size of the lesion produced by this surgery is strain dependent. In C57BL/6J mice, DMCAO produces an infarct predominantly restricted to the barrel region of the somatosensory cortex, but in BALB/cJ mice, DMCAO generates a much larger lesion that incorporates more of the somatosensory cortex and part of the M1 region of the motor cortex. The larger lesion produced by DMCAO in BALB/cJ mice produces a clearer sensorimotor deficit, which is useful for investigating recovery from stroke. We also describe how to modify DMCAO in C57BL/6J mice with the application of hypoxia to generate a lesion and sensorimotor deficit that are similar in size to those produced by DMCAO alone in BALB/cJ mice. This is extremely useful for stroke experiments that require a robust sensorimotor deficit in transgenic mice created on a C57BL/6J background." @default.
• W2277038540 created "2016-06-24" @default.
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• W2277038540 date "2014-01-01" @default.
• W2277038540 modified "2023-10-14" @default.
• W2277038540 title "A Mouse Model of Permanent Focal Ischemia: Distal Middle Cerebral Artery Occlusion" @default.
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• W2277038540 doi "https://doi.org/10.1007/978-1-4939-0320-7_9" @default.
• W2277038540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24510858" @default.
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