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- W2277052853 abstract "Although asymptomatic liver dysfunction is observed in up to one-third of patients who received propylthiouracil, severe hepatotoxicity is rarely seen. Here we report a case of a 47-year-old female with Graves' disease previously having normal liver function tests. After 5 weeks of propylthiouracil administration, she developed jaundice and anorexia. Liver function tests showed elevated aminotransferase and total bilirubin level. Propylthiouracil was discontinued immediately and liver function improved gradually. The patient was uneventful three months after the flare of hepatitis. The diagnosis of propylthiouracil-induced toxic hepatitis was established by the temporal relation between the drug initiation and hepatic dysfunction, and exclusion of other causes of liver damage including viral hepatitis, alcoholic liver disease, autoimmune hepatitis, hereditary disorders, and other hepatotoxins." @default.
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- W2277052853 date "2008-06-01" @default.
- W2277052853 modified "2023-09-24" @default.
- W2277052853 title "Propylthiouracil-Induced Toxic Hepatitis --- Report of One Case" @default.
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- W2277052853 doi "https://doi.org/10.6314/jimt.2008.19(3).11" @default.
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