FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277067672> ?p ?o ?g. }

• W2277067672 endingPage "132" @default.
• W2277067672 startingPage "119" @default.
• W2277067672 abstract "Dendropanax morbifera (D. morbifera), a species endemic to Korea, is largely distributed throughout the southern part of the country. Its leaves, stems, roots, and seeds have been used as a form of alternative medicine for various diseases and neurological disorders including paralysis, stroke, and migraine. However, the molecular mechanisms that underlie the remedial effects of D. morbifera remain largely unknown. In this paper, extracts from D. morbifera leaves were prepared using ethyl acetate as a solvent (abbreviated as DMLE). The modulatory effects of DMLE on neuroinflammation were studied in a lipopolysaccharide (LPS)-stimulated BV2 murine microglial cell line. Production of pro-inflammatory cytokines, activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-[Formula: see text]B), and different M1/M2 activation states of microglia were examined. DMLE treatment suppressed the production of pro-inflammatory cytokines including tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]), interleukin-6 (IL-6), and nitric oxide (NO) in LPS-stimulated BV2 cells. DMLE treatment also attenuated the activation of MAPKs and NF-[Formula: see text]B. In a novel discovery, we found that DMLE up-regulated the marker genes representing an alternative, anti-inflammatory M2 polarization, while suppressing the expression of the classical, pro-inflammatory M1 activation state genes. Here, we uncovered the cellular mechanisms underlying the beneficial effects of D. morbifera against neuroinflammation using BV2 microglia cells. These results strongly suggest that DMLE was able to counter the effects of LPS on BV2 cells via control of microglia polarization states. Additionally, study results indicated that DMLE may have therapeutic potential as a neuroinflammation-suppressing treatment for neurodegenerative diseases." @default.
• W2277067672 created "2016-06-24" @default.
• W2277067672 creator A5009007964 @default.
• W2277067672 creator A5028144504 @default.
• W2277067672 creator A5030936631 @default.
• W2277067672 creator A5038480858 @default.
• W2277067672 creator A5068683682 @default.
• W2277067672 creator A5081284651 @default.
• W2277067672 creator A5089037052 @default.
• W2277067672 date "2016-01-01" @default.
• W2277067672 modified "2023-09-23" @default.
• W2277067672 title "Extracts from Dendropanax morbifera Leaves Have Modulatory Effects on Neuroinflammation in Microglia" @default.
• W2277067672 cites W1568243410 @default.
• W2277067672 cites W1581040284 @default.
• W2277067672 cites W1581947086 @default.
• W2277067672 cites W1585958958 @default.
• W2277067672 cites W1965942744 @default.
• W2277067672 cites W1972296893 @default.
• W2277067672 cites W1986301158 @default.
• W2277067672 cites W2000397914 @default.
• W2277067672 cites W2007193090 @default.
• W2277067672 cites W2011361113 @default.
• W2277067672 cites W2018955138 @default.
• W2277067672 cites W2019155443 @default.
• W2277067672 cites W2019603012 @default.
• W2277067672 cites W2044699444 @default.
• W2277067672 cites W2048817289 @default.
• W2277067672 cites W2050320551 @default.
• W2277067672 cites W2054280241 @default.
• W2277067672 cites W2055107424 @default.
• W2277067672 cites W2057123987 @default.
• W2277067672 cites W2065470571 @default.
• W2277067672 cites W2069181994 @default.
• W2277067672 cites W2072380594 @default.
• W2277067672 cites W2086148521 @default.
• W2277067672 cites W2086840459 @default.
• W2277067672 cites W2089701069 @default.
• W2277067672 cites W2107376426 @default.
• W2277067672 cites W2114395128 @default.
• W2277067672 cites W2123640179 @default.
• W2277067672 cites W2128094952 @default.
• W2277067672 cites W2134685106 @default.
• W2277067672 cites W2147180300 @default.
• W2277067672 cites W2163175900 @default.
• W2277067672 doi "https://doi.org/10.1142/s0192415x16500087" @default.
• W2277067672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26916918" @default.
• W2277067672 hasPublicationYear "2016" @default.
• W2277067672 type Work @default.
• W2277067672 sameAs 2277067672 @default.
• W2277067672 citedByCount "14" @default.
• W2277067672 countsByYear W22770676722016 @default.
• W2277067672 countsByYear W22770676722017 @default.
• W2277067672 countsByYear W22770676722018 @default.
• W2277067672 countsByYear W22770676722019 @default.
• W2277067672 countsByYear W22770676722020 @default.
• W2277067672 countsByYear W22770676722022 @default.
• W2277067672 countsByYear W22770676722023 @default.
• W2277067672 crossrefType "journal-article" @default.
• W2277067672 hasAuthorship W2277067672A5009007964 @default.
• W2277067672 hasAuthorship W2277067672A5028144504 @default.
• W2277067672 hasAuthorship W2277067672A5030936631 @default.
• W2277067672 hasAuthorship W2277067672A5038480858 @default.
• W2277067672 hasAuthorship W2277067672A5068683682 @default.
• W2277067672 hasAuthorship W2277067672A5081284651 @default.
• W2277067672 hasAuthorship W2277067672A5089037052 @default.
• W2277067672 hasConcept C17991360 @default.
• W2277067672 hasConcept C203014093 @default.
• W2277067672 hasConcept C2776914184 @default.
• W2277067672 hasConcept C2779830541 @default.
• W2277067672 hasConcept C86803240 @default.
• W2277067672 hasConcept C87753298 @default.
• W2277067672 hasConcept C95444343 @default.
• W2277067672 hasConcept C98274493 @default.
• W2277067672 hasConceptScore W2277067672C17991360 @default.
• W2277067672 hasConceptScore W2277067672C203014093 @default.
• W2277067672 hasConceptScore W2277067672C2776914184 @default.
• W2277067672 hasConceptScore W2277067672C2779830541 @default.
• W2277067672 hasConceptScore W2277067672C86803240 @default.
• W2277067672 hasConceptScore W2277067672C87753298 @default.
• W2277067672 hasConceptScore W2277067672C95444343 @default.
• W2277067672 hasConceptScore W2277067672C98274493 @default.
• W2277067672 hasIssue "01" @default.
• W2277067672 hasLocation W22770676721 @default.
• W2277067672 hasLocation W22770676722 @default.
• W2277067672 hasOpenAccess W2277067672 @default.
• W2277067672 hasPrimaryLocation W22770676721 @default.
• W2277067672 hasRelatedWork W2040423913 @default.
• W2277067672 hasRelatedWork W2307310199 @default.
• W2277067672 hasRelatedWork W2622610015 @default.
• W2277067672 hasRelatedWork W2889514518 @default.
• W2277067672 hasRelatedWork W2900351260 @default.
• W2277067672 hasRelatedWork W3006433254 @default.
• W2277067672 hasRelatedWork W3162634027 @default.
• W2277067672 hasRelatedWork W4280593573 @default.
• W2277067672 hasRelatedWork W4281290245 @default.
• W2277067672 hasRelatedWork W4300981950 @default.
• W2277067672 hasVolume "44" @default.
• W2277067672 isParatext "false" @default.

• next