Matches in SemOpenAlex for { <https://semopenalex.org/work/W2277071306> ?p ?o ?g. }
- W2277071306 endingPage "4164" @default.
- W2277071306 startingPage "4153" @default.
- W2277071306 abstract "The telencephalon is formed in the most anterior part of the central nervous system (CNS) and is organised into ventral subpallial and dorsal pallial domains. In mice, it has been demonstrated that Fgf signalling has an important role in induction and patterning of the telencephalon. However, the precise role of Fgf signalling is still unclear, owing to overlapping functions of Fgf family genes. To address this, we have examined, in zebrafish embryos, the activation of Ras/mitogen-activated protein kinase (MAPK), one of the major downstream targets of Fgf signalling. Immunohistochemical analysis reveals that an extracellular signal-regulated kinase (ERK), a vertebrate MAPK is activated in the anterior neural boundary (ANB) of the developing CNS at early segmentation stages. Experiments with Fgf inhibitors reveal that ERK activation at this stage is totally dependent on Fgf signalling. Interestingly, a substantial amount of ERK activation is observed in ace mutants in which fgf8 gene is mutated. We then examine the function of Fgf signalling in telencephalic development by use of several inhibitors to Fgf signalling cascade, including dominant-negative forms of Ras (Ras(N17)) and the Fgf receptor (Fgfr), and a chemical inhibitor of Fgfr, SU5402. In treated embryos, the induction of telencephalic territory normally proceeded but the development of the subpallial telencephalon was suppressed, indicating that Fgf signalling is required for the regionalisation within the telencephalon. Finally, antisense experiments with morpholino-modified oligonucleotides suggest that zebrafish fgf3, which is also expressed in the ANB, co-operates with fgf8 in subpallial development." @default.
- W2277071306 created "2016-06-24" @default.
- W2277071306 creator A5005073034 @default.
- W2277071306 creator A5048993236 @default.
- W2277071306 creator A5051500311 @default.
- W2277071306 creator A5082373446 @default.
- W2277071306 creator A5086601107 @default.
- W2277071306 date "2001-11-01" @default.
- W2277071306 modified "2023-09-30" @default.
- W2277071306 title "Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos" @default.
- W2277071306 cites W1547869018 @default.
- W2277071306 cites W1609339746 @default.
- W2277071306 cites W1884216083 @default.
- W2277071306 cites W1902497723 @default.
- W2277071306 cites W1963891523 @default.
- W2277071306 cites W1966341109 @default.
- W2277071306 cites W1967192173 @default.
- W2277071306 cites W1970180329 @default.
- W2277071306 cites W1976754131 @default.
- W2277071306 cites W1976886867 @default.
- W2277071306 cites W1980834418 @default.
- W2277071306 cites W1989897041 @default.
- W2277071306 cites W1992388470 @default.
- W2277071306 cites W1992494265 @default.
- W2277071306 cites W1998756807 @default.
- W2277071306 cites W2003058837 @default.
- W2277071306 cites W2007636457 @default.
- W2277071306 cites W2010585318 @default.
- W2277071306 cites W2012369470 @default.
- W2277071306 cites W2014092680 @default.
- W2277071306 cites W2017204222 @default.
- W2277071306 cites W2031857322 @default.
- W2277071306 cites W2038893023 @default.
- W2277071306 cites W2050387873 @default.
- W2277071306 cites W2050944577 @default.
- W2277071306 cites W2060408023 @default.
- W2277071306 cites W2063928917 @default.
- W2277071306 cites W2068502127 @default.
- W2277071306 cites W2068909924 @default.
- W2277071306 cites W2073810155 @default.
- W2277071306 cites W2104407210 @default.
- W2277071306 cites W2111479560 @default.
- W2277071306 cites W2116428404 @default.
- W2277071306 cites W2125349610 @default.
- W2277071306 cites W2125423296 @default.
- W2277071306 cites W2137536554 @default.
- W2277071306 cites W2138643777 @default.
- W2277071306 cites W2148649613 @default.
- W2277071306 cites W2151407082 @default.
- W2277071306 cites W2159534153 @default.
- W2277071306 cites W2170251919 @default.
- W2277071306 cites W2181939690 @default.
- W2277071306 cites W2182268835 @default.
- W2277071306 cites W2189540589 @default.
- W2277071306 doi "https://doi.org/10.1242/dev.128.21.4153" @default.
- W2277071306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11684653" @default.
- W2277071306 hasPublicationYear "2001" @default.
- W2277071306 type Work @default.
- W2277071306 sameAs 2277071306 @default.
- W2277071306 citedByCount "139" @default.
- W2277071306 countsByYear W22770713062012 @default.
- W2277071306 countsByYear W22770713062013 @default.
- W2277071306 countsByYear W22770713062014 @default.
- W2277071306 countsByYear W22770713062015 @default.
- W2277071306 countsByYear W22770713062016 @default.
- W2277071306 countsByYear W22770713062017 @default.
- W2277071306 countsByYear W22770713062018 @default.
- W2277071306 countsByYear W22770713062019 @default.
- W2277071306 countsByYear W22770713062020 @default.
- W2277071306 countsByYear W22770713062021 @default.
- W2277071306 countsByYear W22770713062022 @default.
- W2277071306 countsByYear W22770713062023 @default.
- W2277071306 crossrefType "journal-article" @default.
- W2277071306 hasAuthorship W2277071306A5005073034 @default.
- W2277071306 hasAuthorship W2277071306A5048993236 @default.
- W2277071306 hasAuthorship W2277071306A5051500311 @default.
- W2277071306 hasAuthorship W2277071306A5082373446 @default.
- W2277071306 hasAuthorship W2277071306A5086601107 @default.
- W2277071306 hasConcept C104317684 @default.
- W2277071306 hasConcept C136571751 @default.
- W2277071306 hasConcept C169760540 @default.
- W2277071306 hasConcept C170493617 @default.
- W2277071306 hasConcept C2776094402 @default.
- W2277071306 hasConcept C2776878037 @default.
- W2277071306 hasConcept C529278444 @default.
- W2277071306 hasConcept C533869091 @default.
- W2277071306 hasConcept C54355233 @default.
- W2277071306 hasConcept C57074206 @default.
- W2277071306 hasConcept C62478195 @default.
- W2277071306 hasConcept C74373430 @default.
- W2277071306 hasConcept C86803240 @default.
- W2277071306 hasConcept C95444343 @default.
- W2277071306 hasConceptScore W2277071306C104317684 @default.
- W2277071306 hasConceptScore W2277071306C136571751 @default.
- W2277071306 hasConceptScore W2277071306C169760540 @default.
- W2277071306 hasConceptScore W2277071306C170493617 @default.
- W2277071306 hasConceptScore W2277071306C2776094402 @default.
- W2277071306 hasConceptScore W2277071306C2776878037 @default.